CBN

CBN or Cannabinol is a mildly psychoactive cannabinoid found only in trace amounts in Cannabis, and is mostly found in aged Cannabis. Pharmacologically relevant quantities are formed as a metabolite of tetrahydrocannabinol (THC). CBN acts as a partial agonist at the CB1 receptors, but has a higher affinity to CB2 receptors; however, it has lower affinities relative to THC.

Chemistry

CBN is a product of THC degradation. Its formation is a result of THC oxidation. The process of THC conversion to CBN is accelerated by exposure to oxygen and heat. Therefore, aged, poorly stored cannabis tends to have higher levels of CBN than fresh plant material.

Pharmacology

CBN is a weak psychoactive compound, with most of its psychoactive effects attributed to its interaction with THC. It has been found to have several therapeutic properties, including pain relief, anti-insomnia, promotes growth of bone cells, antibacterial, anti-inflammatory, and anti-convulsive.

Medical uses

CBN has potential use as a sleep aid due to its sedative effects. It also has potential as a treatment for pain and inflammation, due to its ability to stimulate the release of peptides from sensory nerves. Further research is needed to fully understand the potential medical uses of CBN.

See also

• Cannabis
• Cannabinoids
• Tetrahydrocannabinol

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