Tabernanthine: Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
CSV import
 
Line 1: Line 1:
'''Tabernanthine''' is an [[alkaloid]] that is found in the [[Tabernaemontana]] genus of plants, specifically in the species ''[[Tabernaemontana divaricata]]''. It is a member of the [[iboga]] alkaloid family, which is known for its psychoactive properties.  
{{DISPLAYTITLE:Tabernanthine}}
 
[[File:Tabernanthine.svg|thumb|right|Tabernanthine chemical structure]]
 
'''Tabernanthine''' is an indole alkaloid found in the plant ''[[Tabernanthe iboga]]'', which is native to the rainforests of Central Africa. This compound is one of several alkaloids present in the plant, which is traditionally used in spiritual and healing rituals by indigenous peoples.


==Chemical Structure==
==Chemical Structure==
Tabernanthine is a complex [[organic compound]] with the molecular formula C20H24N2O3. It is a [[tertiary amine]] and contains a [[quinoline]] ring structure. The compound is chiral, meaning it has a non-superimposable mirror image.  
[[File:Tabernanthine_molecule_ball.png|thumb|left|Tabernanthine molecule ball-and-stick model]]
Tabernanthine is structurally related to other indole alkaloids such as [[ibogaine]], which is also found in ''Tabernanthe iboga''. The chemical structure of tabernanthine includes a complex arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, forming a characteristic indole ring system. This structure is crucial for its biological activity and interaction with various receptors in the human body.
 
==Pharmacology==
Tabernanthine, like other alkaloids from ''Tabernanthe iboga'', interacts with the central nervous system. It is believed to have psychoactive properties, although its specific effects and mechanisms of action are less well-studied compared to ibogaine. The compound may influence neurotransmitter systems, potentially affecting mood, perception, and cognition.


==Biosynthesis==
==Uses and Effects==
The biosynthesis of tabernanthine involves the condensation of [[tryptamine]] and [[secologanin]] to form [[strictosidine]], which is then converted to tabernanthine through a series of enzymatic reactions.  
In traditional settings, ''Tabernanthe iboga'' is used in low doses as a stimulant and in higher doses for its psychoactive effects during initiation rites and healing ceremonies. The role of tabernanthine in these effects is not fully understood, but it is thought to contribute to the overall psychoactive profile of the plant.


==Pharmacology==
==Safety and Toxicity==
Tabernanthine has been found to have several pharmacological effects. It has been shown to have [[antinociceptive]] properties, meaning it can reduce sensitivity to painful stimuli. It also has [[antimicrobial]] activity, and has been found to inhibit the growth of certain bacteria and fungi.  
The safety profile of tabernanthine is not well-documented, and caution is advised when considering its use. Like ibogaine, it may pose risks of toxicity, particularly at higher doses. Potential adverse effects could include cardiovascular complications and neurotoxicity, although specific data on tabernanthine is limited.


==Medical Uses==
==Research and Potential==
While tabernanthine is not currently used in mainstream medicine, it has been used in traditional medicine for its analgesic and antimicrobial properties. There is also ongoing research into its potential use in the treatment of [[addiction]].
Research into tabernanthine is ongoing, with interest in its potential therapeutic applications. Studies are exploring its effects on the brain and its possible use in treating conditions such as addiction and depression. However, more research is needed to fully understand its pharmacological properties and therapeutic potential.


==See Also==
==Related Pages==
* [[Ibogaine]]
* [[Ibogaine]]
* [[Tabernaemontana divaricata]]
* [[Indole alkaloid]]
* [[Alkaloid]]
* [[Tabernanthe iboga]]
* [[Psychoactive plant]]


[[Category:Alkaloids]]
[[Category:Indole alkaloids]]
[[Category:Psychoactive drugs]]
[[Category:Psychoactive drugs]]
[[Category:Tabernaemontana]]
[[Category:Chemical compounds found in plants]]
 
{{stub}}
<gallery>
File:Tabernanthine.svg|Tabernanthine structure diagram
File:Tabernanthine_molecule_ball.png|Tabernanthine molecule ball-and-stick model
</gallery>
== Tabernanthine ==
<gallery>
File:Tabernanthine.svg|Tabernanthine chemical structure
File:Tabernanthine_molecule_ball.png|Tabernanthine molecule ball-and-stick model
</gallery>

Latest revision as of 11:09, 23 March 2025


Tabernanthine chemical structure

Tabernanthine is an indole alkaloid found in the plant Tabernanthe iboga, which is native to the rainforests of Central Africa. This compound is one of several alkaloids present in the plant, which is traditionally used in spiritual and healing rituals by indigenous peoples.

Chemical Structure[edit]

File:Tabernanthine molecule ball.png
Tabernanthine molecule ball-and-stick model

Tabernanthine is structurally related to other indole alkaloids such as ibogaine, which is also found in Tabernanthe iboga. The chemical structure of tabernanthine includes a complex arrangement of carbon, hydrogen, nitrogen, and oxygen atoms, forming a characteristic indole ring system. This structure is crucial for its biological activity and interaction with various receptors in the human body.

Pharmacology[edit]

Tabernanthine, like other alkaloids from Tabernanthe iboga, interacts with the central nervous system. It is believed to have psychoactive properties, although its specific effects and mechanisms of action are less well-studied compared to ibogaine. The compound may influence neurotransmitter systems, potentially affecting mood, perception, and cognition.

Uses and Effects[edit]

In traditional settings, Tabernanthe iboga is used in low doses as a stimulant and in higher doses for its psychoactive effects during initiation rites and healing ceremonies. The role of tabernanthine in these effects is not fully understood, but it is thought to contribute to the overall psychoactive profile of the plant.

Safety and Toxicity[edit]

The safety profile of tabernanthine is not well-documented, and caution is advised when considering its use. Like ibogaine, it may pose risks of toxicity, particularly at higher doses. Potential adverse effects could include cardiovascular complications and neurotoxicity, although specific data on tabernanthine is limited.

Research and Potential[edit]

Research into tabernanthine is ongoing, with interest in its potential therapeutic applications. Studies are exploring its effects on the brain and its possible use in treating conditions such as addiction and depression. However, more research is needed to fully understand its pharmacological properties and therapeutic potential.

Related Pages[edit]