Tiapamil

Tiapamil is a calcium channel blocker used in the treatment of cardiovascular disease. It is a non-dihydropyridine member of the phenylalkylamine class, similar to verapamil.

Pharmacology

Tiapamil acts by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells. This inhibition results in the relaxation of these muscles, leading to a decrease in blood pressure and a reduction in heart rate. It also has anti-arrhythmia properties, making it useful in the treatment of conditions such as atrial fibrillation and supraventricular tachycardia.

Clinical Use

Tiapamil is used in the management of hypertension, angina pectoris, and certain types of cardiac arrhythmias. It is also used off-label for the prevention of migraine headaches.

Side Effects

Common side effects of Tiapamil include dizziness, fatigue, nausea, and constipation. Less common but more serious side effects can include bradycardia, hypotension, and heart block.

Contraindications

Tiapamil is contraindicated in patients with severe heart failure, significant bradycardia, and second- or third-degree heart block without a functioning pacemaker.

Drug Interactions

Tiapamil can interact with a number of other medications, including beta blockers, digoxin, and statins. These interactions can lead to increased levels of these medications in the body, potentially resulting in toxicity.

See Also

• Calcium channel blocker
• Verapamil
• Cardiovascular disease
• Hypertension
• Angina pectoris

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• Tiapamil
  Tiapamil
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  Dimeditiapramine
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  Dimeditiapramine 3D spacefill

Tiapamil

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  Dimeditiapramine chemical structure
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  Dimeditiapramine 3D space-filling model