Intravascular lymphomas: Difference between revisions
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{{Infobox medical condition | |||
| name = Intravascular lymphomas | |||
| image = [[File:Intravascular_lymphoma_-_very_high_mag.jpg|250px]] | |||
| caption = Micrograph of intravascular lymphoma, very high magnification | |||
| field = [[Hematology]] | |||
| symptoms = [[Fever]], [[weight loss]], [[neurological symptoms]], [[skin lesions]] | |||
| complications = [[Organ failure]], [[thrombosis]] | |||
| onset = Typically in [[adulthood]] | |||
| duration = [[Chronic (medicine)|Chronic]] | |||
| types = [[B-cell lymphoma]], [[T-cell lymphoma]] | |||
| causes = Unknown | |||
| risks = [[Immunosuppression]], [[genetic predisposition]] | |||
| diagnosis = [[Biopsy]], [[immunohistochemistry]] | |||
| differential = [[Vasculitis]], [[sepsis]], [[metastatic carcinoma]] | |||
| treatment = [[Chemotherapy]], [[immunotherapy]] | |||
| prognosis = Generally poor | |||
| frequency = Rare | |||
}} | |||
'''Intravascular lymphomas''' are a rare subtype of [[extranodal lymphoma]] that are characterized by the selective growth of [[lymphoma cells]] within the lumen of [[blood vessels]], particularly the [[capillaries]], rather than in the [[lymph nodes]]. The disease affects adults and is usually systemic at diagnosis, with a predilection for the [[central nervous system]] and [[skin]]. | '''Intravascular lymphomas''' are a rare subtype of [[extranodal lymphoma]] that are characterized by the selective growth of [[lymphoma cells]] within the lumen of [[blood vessels]], particularly the [[capillaries]], rather than in the [[lymph nodes]]. The disease affects adults and is usually systemic at diagnosis, with a predilection for the [[central nervous system]] and [[skin]]. | ||
== Clinical Presentation == | == Clinical Presentation == | ||
The clinical presentation of intravascular lymphomas is often nonspecific and can vary widely, depending on the organs involved. Symptoms may include [[fever]], [[fatigue]], [[weight loss]], [[neurologic symptoms]], and [[skin lesions]]. Because of the nonspecific symptoms and the rarity of the disease, diagnosis is often delayed. | The clinical presentation of intravascular lymphomas is often nonspecific and can vary widely, depending on the organs involved. Symptoms may include [[fever]], [[fatigue]], [[weight loss]], [[neurologic symptoms]], and [[skin lesions]]. Because of the nonspecific symptoms and the rarity of the disease, diagnosis is often delayed. | ||
== Diagnosis == | == Diagnosis == | ||
Diagnosis of intravascular lymphomas is challenging due to the lack of specific symptoms and the absence of [[lymphadenopathy]] or [[hepatosplenomegaly]]. The diagnosis is often made by [[biopsy]] of involved organs or tissues. [[Immunohistochemistry]] is used to confirm the diagnosis, with the lymphoma cells typically expressing [[CD20]], a B-cell marker. | Diagnosis of intravascular lymphomas is challenging due to the lack of specific symptoms and the absence of [[lymphadenopathy]] or [[hepatosplenomegaly]]. The diagnosis is often made by [[biopsy]] of involved organs or tissues. [[Immunohistochemistry]] is used to confirm the diagnosis, with the lymphoma cells typically expressing [[CD20]], a B-cell marker. | ||
== Treatment == | == Treatment == | ||
Treatment of intravascular lymphomas typically involves [[chemotherapy]], often with a regimen that includes [[rituximab]], a monoclonal antibody against CD20. The prognosis is generally poor, with a median survival of less than two years, but early diagnosis and aggressive treatment can improve survival. | Treatment of intravascular lymphomas typically involves [[chemotherapy]], often with a regimen that includes [[rituximab]], a monoclonal antibody against CD20. The prognosis is generally poor, with a median survival of less than two years, but early diagnosis and aggressive treatment can improve survival. | ||
== See Also == | == See Also == | ||
* [[Lymphoma]] | * [[Lymphoma]] | ||
* [[Extranodal lymphoma]] | * [[Extranodal lymphoma]] | ||
* [[CD20]] | * [[CD20]] | ||
* [[Rituximab]] | * [[Rituximab]] | ||
== References == | == References == | ||
<references /> | <references /> | ||
{{stub}} | {{stub}} | ||
[[Category:Medical Conditions]] | [[Category:Medical Conditions]] | ||
[[Category:Lymphomas]] | [[Category:Lymphomas]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 21:24, 6 April 2025
Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD's medical weight loss NYC, sleep center NYC
Philadelphia medical weight loss and Philadelphia sleep clinics
| Intravascular lymphomas | |
|---|---|
| |
| Synonyms | N/A |
| Pronounce | N/A |
| Specialty | N/A |
| Symptoms | Fever, weight loss, neurological symptoms, skin lesions |
| Complications | Organ failure, thrombosis |
| Onset | Typically in adulthood |
| Duration | Chronic |
| Types | B-cell lymphoma, T-cell lymphoma |
| Causes | Unknown |
| Risks | Immunosuppression, genetic predisposition |
| Diagnosis | Biopsy, immunohistochemistry |
| Differential diagnosis | Vasculitis, sepsis, metastatic carcinoma |
| Prevention | N/A |
| Treatment | Chemotherapy, immunotherapy |
| Medication | N/A |
| Prognosis | Generally poor |
| Frequency | Rare |
| Deaths | N/A |
Intravascular lymphomas are a rare subtype of extranodal lymphoma that are characterized by the selective growth of lymphoma cells within the lumen of blood vessels, particularly the capillaries, rather than in the lymph nodes. The disease affects adults and is usually systemic at diagnosis, with a predilection for the central nervous system and skin.
Clinical Presentation[edit]
The clinical presentation of intravascular lymphomas is often nonspecific and can vary widely, depending on the organs involved. Symptoms may include fever, fatigue, weight loss, neurologic symptoms, and skin lesions. Because of the nonspecific symptoms and the rarity of the disease, diagnosis is often delayed.
Diagnosis[edit]
Diagnosis of intravascular lymphomas is challenging due to the lack of specific symptoms and the absence of lymphadenopathy or hepatosplenomegaly. The diagnosis is often made by biopsy of involved organs or tissues. Immunohistochemistry is used to confirm the diagnosis, with the lymphoma cells typically expressing CD20, a B-cell marker.
Treatment[edit]
Treatment of intravascular lymphomas typically involves chemotherapy, often with a regimen that includes rituximab, a monoclonal antibody against CD20. The prognosis is generally poor, with a median survival of less than two years, but early diagnosis and aggressive treatment can improve survival.
See Also[edit]
References[edit]
<references />
