OR10AD1

OR10AD1 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor Family 10 Subfamily AD Member 1. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

The OR10AD1 gene is located on chromosome 15q25.1 and is expressed in the olfactory epithelium. The function of the OR10AD1 protein is not well understood, but it is thought to play a role in the detection of odorants.

Structure

The OR10AD1 gene is composed of a single coding exon. The protein encoded by this gene is a member of the G protein-coupled receptor superfamily. This protein, like other members of this family, has a structure that includes seven transmembrane domains. This structure is common to many receptors that detect molecules outside the cell and activate cellular responses.

Function

The OR10AD1 protein is thought to be involved in the detection of odorants. It is expressed in the olfactory epithelium, the tissue in the nose that contains the olfactory receptors. When an odorant molecule binds to the OR10AD1 protein, it triggers a signal transduction pathway that leads to the perception of smell.

Clinical significance

The role of OR10AD1 in disease is not well understood. However, changes in the function of olfactory receptors can affect the sense of smell, which can have a significant impact on quality of life. Further research is needed to understand the potential role of OR10AD1 in disease.

See also

• Olfactory receptor
• G protein-coupled receptor
• Olfactory epithelium

References

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