Isodisomy

Isodisomy is a type of uniparental disomy where two copies of a chromosome or part of a chromosome are inherited from one parent. This can occur as a result of meiotic non-disjunction or post-zygotic chromosomal duplication. Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved.

Causes

Isodisomy can occur as a result of two main processes: meiotic non-disjunction and post-zygotic chromosomal duplication.

In meiotic non-disjunction, both copies of a chromosome from one parent are passed on to the offspring. This can occur in either the first or second division of meiosis.

Post-zygotic chromosomal duplication occurs after fertilization, when a single copy of a chromosome duplicates itself to produce two identical copies.

Genetic Disorders

Isodisomy can lead to a number of genetic disorders, depending on the specific chromosomes involved. These can include Prader-Willi syndrome, Angelman syndrome, and Beckwith-Wiedemann syndrome, among others.

In these disorders, the presence of two identical copies of a chromosome from one parent leads to an imbalance in genetic material, which can disrupt normal development and lead to a range of health problems.

See Also

• Uniparental disomy
• Genetic disorder
• Chromosome
• Meiosis

References

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