KCNAB2

KCNAB2 is a gene that encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits.

Function

The KCNAB2 gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. These proteins function as voltage-gated potassium channels, which are integral membrane proteins that open or close in response to changes in the voltage across the plasma membrane.

The encoded protein forms a heteromultimeric complex with Kv-alpha subunits, which regulates the function of these channels. This protein also interacts with the Kv-beta subunits, and it may increase the current amplitude of the potassium channel with which it interacts.

Clinical Significance

Mutations in the KCNAB2 gene have been associated with episodic ataxia, a neurological condition characterized by episodes of poor coordination and balance (ataxia).

See Also

• Voltage-gated potassium channel
• Kv-alpha subunits
• Kv-beta subunits

References

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External Links

• KCNAB2 at the National Center for Biotechnology Information

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