OR7C1

OR7C1 is a gene that encodes the olfactory receptor protein, OR7C1. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Function

The OR7C1 gene is part of the olfactory receptor family, which is involved in the detection of smell. The protein encoded by this gene is a G protein-coupled receptor that is expressed in the olfactory epithelium of the nose. When an odor molecule binds to OR7C1, it triggers a signal transduction pathway that results in the perception of smell.

Structure

The OR7C1 protein is a member of the GPCR family, which are characterized by their seven transmembrane domains. These domains form a pocket in the cell membrane where odor molecules can bind. The binding of an odor molecule to OR7C1 triggers a conformational change in the protein, which activates the G protein and initiates the signal transduction pathway.

Clinical Significance

While the exact role of OR7C1 in human health and disease is not fully understood, it is known that mutations in olfactory receptor genes can lead to a loss of smell, a condition known as anosmia. Further research is needed to determine the specific role of OR7C1 in this and other conditions.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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