Ethadione: Difference between revisions
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Revision as of 01:04, 20 February 2025
Ethadione is an anticonvulsant that was used to treat various types of seizure disorders. It was withdrawn from the market due to its adverse effects on the fetus.
History
Ethadione was first synthesized in the 1950s and was used as an anticonvulsant for several decades. However, it was withdrawn from the market due to its teratogenic effects, which can cause birth defects in the fetus.
Mechanism of Action
Ethadione works by inhibiting the spread of seizure activity in the brain. It does this by reducing the abnormal electrical activity in the brain.
Side Effects
The side effects of ethadione include dizziness, nausea, and vomiting. In rare cases, it can cause skin rash, jaundice, and anemia. The most serious side effect is its teratogenic effect, which can cause birth defects in the fetus.
Contraindications
Ethadione is contraindicated in pregnant women due to its teratogenic effects. It is also contraindicated in patients with liver disease or blood disorders.
Interactions
Ethadione can interact with other anticonvulsants, increasing their effects and potentially causing toxicity. It can also interact with alcohol, increasing its effects and potentially causing drowsiness and impaired coordination.
Withdrawal
Ethadione was withdrawn from the market due to its teratogenic effects. However, it is still available in some countries for use in patients who cannot tolerate other anticonvulsants.
