UCP2

A protein involved in mitochondrial function and energy regulation

Mitochondrial uncoupling protein 2 (UCP2) is a protein that in humans is encoded by the UCP2 gene. It is a member of the mitochondrial carrier family and is involved in the regulation of energy balance and metabolism.

Function

UCP2 is located in the inner mitochondrial membrane and functions to dissipate the proton gradient generated by the electron transport chain. This process, known as proton leak, reduces the efficiency of oxidative phosphorylation and results in the generation of heat instead of ATP. UCP2 is thought to play a role in the regulation of reactive oxygen species (ROS) production and may be involved in the protection against oxidative stress.

Expression

UCP2 is expressed in a wide range of tissues, including the brain, pancreas, and adipose tissue. Its expression is regulated by various factors, including diet, hormones, and temperature.

Role in Disease

UCP2 has been implicated in several diseases, including obesity, diabetes, and cancer. Its role in these conditions is complex and not fully understood. In obesity and diabetes, UCP2 may influence energy expenditure and insulin secretion. In cancer, UCP2 may affect cell proliferation and survival.

Research

Research on UCP2 continues to explore its potential as a therapeutic target for metabolic diseases. Studies are investigating how modulation of UCP2 activity could influence metabolic rate and ROS production.

Related pages

• Mitochondrion
• Oxidative phosphorylation
• Reactive oxygen species

References

File:MMDB ID 92271 PDB ID 2LCK Mitochondrial Uncoupling Protein 2.png

Structure of mitochondrial uncoupling protein 2 (UCP2)

• Mitochondrial Uncoupling Protein 2
  Mitochondrial Uncoupling Protein 2