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'''Valter Longo''' is an Italian-American biogerontologist and cell biologist known for his research on the role of [[fasting]] and [[nutrient]] response genes in promoting longevity and healthspan. He is a professor of gerontology and biological sciences at the [[University of Southern California]] (USC) and the director of the USC Longevity Institute.
{{Short description|Italian-American biogerontologist and cell biologist}}
{{Use dmy dates|date=October 2023}}


== Early Life and Education ==
[[File:Valter_Longo_2022.png|thumb|Valter Longo in 2022]]
Valter Longo was born in [[Genoa]], [[Italy]]. He moved to the [[United States]] to pursue higher education. Longo received his undergraduate degree in biochemistry from the [[University of North Texas]] and later earned his Ph.D. in biochemistry from the [[University of California, Los Angeles]] (UCLA).
'''Valter D. Longo''' (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his research on the role of fasting and nutrient response genes in aging and diseases. He is a professor of gerontology and biological sciences at the [[University of Southern California]] (USC) and the director of the USC Longevity Institute.


== Research and Contributions ==
==Early life and education==
Longo's research primarily focuses on the mechanisms of aging and the development of dietary interventions to promote longevity. He is best known for his work on the [[Fasting Mimicking Diet]] (FMD), a dietary regimen designed to mimic the effects of fasting while providing essential nutrients. This diet has been shown to have various health benefits, including improved metabolic health, reduced risk of chronic diseases, and enhanced longevity.
Valter Longo was born in [[Genoa]], [[Italy]]. He moved to the [[United States]] at the age of 16 as an exchange student. Longo attended the [[University of North Texas]] where he received his undergraduate degree in biochemistry. He then pursued a Ph.D. in biochemistry at the [[University of California, Los Angeles]] (UCLA), where he studied under the guidance of [[Roy Walford]], a pioneer in the field of caloric restriction and aging.


=== Fasting and Longevity ===
==Career==
Longo's studies have demonstrated that periodic fasting can activate cellular pathways that promote stress resistance, cellular repair, and regeneration. His research has shown that fasting can reduce the levels of [[insulin-like growth factor 1]] (IGF-1), a hormone associated with aging and cancer, and increase the levels of protective proteins such as [[sirtuins]] and [[autophagy]]-related proteins.
After completing his Ph.D., Longo conducted postdoctoral research at the [[University of Southern California]] in the laboratory of [[Caleb Finch]], focusing on the genetic mechanisms of aging. He later joined the faculty at USC, where he established his own laboratory to study the molecular pathways involved in aging and age-related diseases.


=== ProLon Diet ===
Longo's research has primarily focused on the effects of fasting and caloric restriction on longevity and healthspan. He has identified several key nutrient-sensing pathways, such as the [[IGF-1]] and [[mTOR]] pathways, that play crucial roles in the aging process. His work has led to the development of the "Fasting Mimicking Diet" (FMD), a dietary regimen designed to mimic the effects of fasting while providing essential nutrients.
Longo is also the creator of the ProLon diet, a commercially available version of the Fasting Mimicking Diet. The ProLon diet is a five-day meal program that provides the body with essential nutrients while mimicking the effects of fasting. It has gained popularity for its potential health benefits, including weight loss, improved metabolic health, and reduced inflammation.


== Awards and Recognition ==
==Research and contributions==
Valter Longo has received numerous awards for his contributions to the field of aging and longevity, including the [[Nathan Shock Award]] from the [[National Institute on Aging]] and the [[Merz Professorship]] in Aging Research.
Longo's research has demonstrated that periodic fasting can have beneficial effects on health and longevity. His studies have shown that fasting can protect normal cells while making cancer cells more susceptible to chemotherapy. This has led to clinical trials investigating the potential of fasting as an adjunct to cancer treatment.


== Publications ==
In addition to his work on fasting, Longo has explored the role of specific genes in aging and disease. His research has identified several "longevity genes" that are conserved across species and are involved in the regulation of lifespan and healthspan.
Longo has published extensively in scientific journals and has authored several books on aging and nutrition. His book, "The Longevity Diet," outlines his dietary recommendations for promoting health and longevity based on his research findings.


== See Also ==
==Publications and books==
* [[Gerontology]]
Valter Longo has published numerous scientific articles in prestigious journals such as ''[[Cell (journal)|Cell]]'', ''[[Nature (journal)|Nature]]'', and ''[[Science (journal)|Science]]''. He is also the author of the book "The Longevity Diet," which outlines his dietary recommendations for promoting health and longevity based on his research findings.
 
==Awards and recognition==
Longo has received several awards for his contributions to the field of aging research, including the Nathan Shock Award from the [[National Institute on Aging]] and the Vincent Cristofalo Rising Star Award in Aging Research from the [[American Federation for Aging Research]].
 
==Related pages==
* [[Caloric restriction]]
* [[Caloric restriction]]
* [[Autophagy]]
* [[Fasting]]
* [[Sirtuins]]
* [[Longevity]]
* [[Insulin-like growth factor 1]]
* [[Biogerontology]]


== References ==
==References==
{{Reflist}}
{{Reflist}}


== External Links ==
==External links==
{{Authority control}}
* [https://gero.usc.edu/faculty/longo/ Valter Longo's profile at USC]
* [https://www.valterlongo.com/ Valter Longo's personal website]


[[Category:1967 births]]
[[Category:Living people]]
[[Category:Living people]]
[[Category:American biologists]]
[[Category:American biologists]]
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[[Category:University of North Texas alumni]]
[[Category:University of North Texas alumni]]
[[Category:University of California, Los Angeles alumni]]
[[Category:University of California, Los Angeles alumni]]
[[Category:Biogerontologists]]
{{medicine-stub}}

Revision as of 12:02, 9 February 2025

Italian-American biogerontologist and cell biologist



File:Valter Longo 2022.png
Valter Longo in 2022

Valter D. Longo (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his research on the role of fasting and nutrient response genes in aging and diseases. He is a professor of gerontology and biological sciences at the University of Southern California (USC) and the director of the USC Longevity Institute.

Early life and education

Valter Longo was born in Genoa, Italy. He moved to the United States at the age of 16 as an exchange student. Longo attended the University of North Texas where he received his undergraduate degree in biochemistry. He then pursued a Ph.D. in biochemistry at the University of California, Los Angeles (UCLA), where he studied under the guidance of Roy Walford, a pioneer in the field of caloric restriction and aging.

Career

After completing his Ph.D., Longo conducted postdoctoral research at the University of Southern California in the laboratory of Caleb Finch, focusing on the genetic mechanisms of aging. He later joined the faculty at USC, where he established his own laboratory to study the molecular pathways involved in aging and age-related diseases.

Longo's research has primarily focused on the effects of fasting and caloric restriction on longevity and healthspan. He has identified several key nutrient-sensing pathways, such as the IGF-1 and mTOR pathways, that play crucial roles in the aging process. His work has led to the development of the "Fasting Mimicking Diet" (FMD), a dietary regimen designed to mimic the effects of fasting while providing essential nutrients.

Research and contributions

Longo's research has demonstrated that periodic fasting can have beneficial effects on health and longevity. His studies have shown that fasting can protect normal cells while making cancer cells more susceptible to chemotherapy. This has led to clinical trials investigating the potential of fasting as an adjunct to cancer treatment.

In addition to his work on fasting, Longo has explored the role of specific genes in aging and disease. His research has identified several "longevity genes" that are conserved across species and are involved in the regulation of lifespan and healthspan.

Publications and books

Valter Longo has published numerous scientific articles in prestigious journals such as Cell, Nature, and Science. He is also the author of the book "The Longevity Diet," which outlines his dietary recommendations for promoting health and longevity based on his research findings.

Awards and recognition

Longo has received several awards for his contributions to the field of aging research, including the Nathan Shock Award from the National Institute on Aging and the Vincent Cristofalo Rising Star Award in Aging Research from the American Federation for Aging Research.

Related pages

References

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External links