Amrinone: Difference between revisions

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'''Amrinone''' or '''Inamrinone''' is a type of [[phosphodiesterase inhibitor]] used primarily in the treatment of [[congestive heart failure]] (CHF). It works by inhibiting the enzyme [[phosphodiesterase 3]] (PDE3), which leads to an increase in [[intracellular]] [[cAMP]] and improved [[cardiac output]] without a significant increase in [[heart rate]]. Amrinone is classified as a [[positive inotrope]], meaning it increases the strength of the heart's contractions, and a [[vasodilator]], as it widens blood vessels, reducing the workload on the heart.
{{Short description|A traditional Filipino puffed rice snack}}
{{Use dmy dates|date=October 2023}}


==Mechanism of Action==
'''Ampaw''' (also spelled '''ampao''') is a traditional Filipino snack made from puffed rice. It is a popular treat in the Philippines, known for its light and airy texture and sweet flavor. Ampaw is often enjoyed as a snack or dessert and is commonly found in local markets and festivals.
Amrinone acts by inhibiting PDE3, an enzyme that breaks down cAMP. The accumulation of cAMP leads to an increase in [[calcium]] ions within [[cardiac muscle]] cells, enhancing [[myocardial contractility]] (the ability of the heart muscle to contract) and leading to a positive inotropic effect. Additionally, the vasodilatory effect is achieved through the relaxation of [[vascular smooth muscle]], which results in decreased [[peripheral vascular resistance]] and reduced afterload on the heart.


==Clinical Use==
==History==
Amrinone is used in the management of acute exacerbations of CHF, where it can improve symptoms and increase cardiac output. It is often administered intravenously in a hospital setting due to its potent effects and the need for close monitoring of the patient.
Ampaw has a long history in the Philippines, with its origins tracing back to the influence of Chinese immigrants who introduced the technique of puffing rice. Over time, the recipe was adapted to local tastes, incorporating native ingredients and flavors. It became a staple snack in various regions, particularly in [[Cebu]] and [[Bulacan]].


==Side Effects==
==Preparation==
The use of Amrinone can be associated with several side effects, including [[thrombocytopenia]] (a decrease in the number of [[platelets]] in the blood, which can lead to increased bleeding), [[arrhythmias]] (irregular heartbeats), and [[hypotension]] (low blood pressure). Due to these potential side effects, careful monitoring of the patient is required during treatment.
The preparation of ampaw involves several steps:


==Comparison with Other Therapies==
# '''Rice Selection''': The process begins with selecting the right type of rice, usually glutinous rice, which is known for its sticky texture when cooked.
Amrinone is one of several drugs available for the treatment of CHF. It is often compared to [[digoxin]], another positive inotrope, and [[beta blockers]], which have a different mechanism of action but are also used in the management of CHF. Unlike digoxin, Amrinone does not have a direct effect on the [[autonomic nervous system]], and its use is typically reserved for acute settings rather than long-term management.
# '''Cooking and Drying''': The rice is cooked and then dried thoroughly to remove moisture, which is crucial for the puffing process.
# '''Puffing''': The dried rice is then puffed using high heat. Traditionally, this was done by frying the rice in hot sand, a method that allows the rice to expand quickly without burning.
# '''Coating''': Once puffed, the rice is coated with a syrup made from sugar and sometimes honey, which acts as a binding agent and adds sweetness.
# '''Molding and Cooling''': The coated rice is then molded into desired shapes and sizes, often rectangular or round, and left to cool and harden.


==Limitations and Considerations==
==Regional Variations==
The use of Amrinone is limited by its side effects, particularly the risk of thrombocytopenia and the potential for arrhythmias. It is also contraindicated in patients with severe [[aortic stenosis]] due to the risk of exacerbating outflow obstruction. Furthermore, the benefits of Amrinone in long-term management of CHF are less clear, and it is generally not used as a first-line treatment for chronic CHF.
While the basic process of making ampaw is similar across the Philippines, there are regional variations:


==Conclusion==
* '''Cebu''': In Cebu, ampaw is often larger and has a distinct caramel flavor. It is a popular pasalubong (souvenir) item for tourists.
Amrinone serves as an important option in the acute management of CHF, particularly in cases where rapid improvement in cardiac output is needed. However, its use must be carefully balanced against the potential for significant side effects, and it is typically employed as part of a broader treatment strategy that may include other medications and interventions aimed at managing CHF.
* '''Bulacan''': The version from Bulacan is known for its crispiness and is sometimes flavored with local ingredients such as [[pandan]] or [[coconut]].


[[Category:Cardiac drugs]]
==Cultural Significance==
[[Category:Phosphodiesterase inhibitors]]
Ampaw is more than just a snack; it holds cultural significance in Filipino society. It is often associated with childhood memories and is a staple during local festivals and celebrations. The snack is also a symbol of Filipino ingenuity, showcasing how traditional methods can create delightful treats from simple ingredients.


{{medicine-stub}}
==Related pages==
* [[Puffed rice]]
* [[Filipino cuisine]]
* [[Pasalubong]]
 
==Gallery==
<gallery>
File:Ampao_from_Carcar,_Cebu.jpg|Ampaw from Carcar, Cebu
File:5134Cuisine_foods_of_Bulacan_09.jpg|Ampaw from Bulacan
</gallery>
 
[[Category:Filipino cuisine]]
[[Category:Snack foods]]

Revision as of 18:31, 11 February 2025

A traditional Filipino puffed rice snack



Ampaw (also spelled ampao) is a traditional Filipino snack made from puffed rice. It is a popular treat in the Philippines, known for its light and airy texture and sweet flavor. Ampaw is often enjoyed as a snack or dessert and is commonly found in local markets and festivals.

History

Ampaw has a long history in the Philippines, with its origins tracing back to the influence of Chinese immigrants who introduced the technique of puffing rice. Over time, the recipe was adapted to local tastes, incorporating native ingredients and flavors. It became a staple snack in various regions, particularly in Cebu and Bulacan.

Preparation

The preparation of ampaw involves several steps:

  1. Rice Selection: The process begins with selecting the right type of rice, usually glutinous rice, which is known for its sticky texture when cooked.
  2. Cooking and Drying: The rice is cooked and then dried thoroughly to remove moisture, which is crucial for the puffing process.
  3. Puffing: The dried rice is then puffed using high heat. Traditionally, this was done by frying the rice in hot sand, a method that allows the rice to expand quickly without burning.
  4. Coating: Once puffed, the rice is coated with a syrup made from sugar and sometimes honey, which acts as a binding agent and adds sweetness.
  5. Molding and Cooling: The coated rice is then molded into desired shapes and sizes, often rectangular or round, and left to cool and harden.

Regional Variations

While the basic process of making ampaw is similar across the Philippines, there are regional variations:

  • Cebu: In Cebu, ampaw is often larger and has a distinct caramel flavor. It is a popular pasalubong (souvenir) item for tourists.
  • Bulacan: The version from Bulacan is known for its crispiness and is sometimes flavored with local ingredients such as pandan or coconut.

Cultural Significance

Ampaw is more than just a snack; it holds cultural significance in Filipino society. It is often associated with childhood memories and is a staple during local festivals and celebrations. The snack is also a symbol of Filipino ingenuity, showcasing how traditional methods can create delightful treats from simple ingredients.

Related pages

Gallery