GSK-4112: Difference between revisions
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'''GSK-4112''' | == GSK-4112 == | ||
[[File:GSK-4112_Structure.svg|thumb|right|Chemical structure of GSK-4112]] | |||
'''GSK-4112''' is a synthetic chemical compound that acts as a selective ligand for the nuclear receptor [[Rev-ErbA alpha]]. It is primarily used in research to study the physiological roles of Rev-ErbA alpha, which is involved in the regulation of circadian rhythm, metabolism, and inflammation. | |||
== Mechanism of Action == | == Mechanism of Action == | ||
GSK-4112 functions | GSK-4112 functions as an agonist of the Rev-ErbA alpha receptor. By binding to this receptor, GSK-4112 influences the transcription of genes involved in various biological processes. The activation of Rev-ErbA alpha by GSK-4112 leads to the repression of target genes, which can affect the [[circadian clock]], lipid metabolism, and [[glucose homeostasis]]. | ||
== Biological Effects == | |||
The activation of Rev-ErbA alpha by GSK-4112 has been shown to have several biological effects: | |||
* '''Circadian Rhythm Regulation''': GSK-4112 can modulate the expression of core clock genes, thereby influencing the circadian rhythm. | |||
* '''Metabolic Effects''': It affects lipid and glucose metabolism, potentially offering insights into the treatment of metabolic disorders. | |||
* '''Inflammation''': GSK-4112 has been studied for its role in modulating inflammatory responses, which could have implications for diseases characterized by chronic inflammation. | |||
== | == Research Applications == | ||
GSK-4112 is used extensively in [[biomedical research]] to explore the functions of Rev-ErbA alpha. It serves as a tool compound to dissect the pathways regulated by this nuclear receptor and to understand its role in various physiological and pathological conditions. | |||
== | == Related Pages == | ||
* [[Rev-ErbA alpha]] | * [[Rev-ErbA alpha]] | ||
* [[Circadian rhythm]] | * [[Circadian rhythm]] | ||
* [[Nuclear receptor]] | |||
* [[Metabolism]] | * [[Metabolism]] | ||
[[Category: | [[Category:Chemical compounds]] | ||
[[Category: | [[Category:Pharmacology]] | ||
[[Category: | [[Category:Research tools]] | ||
Latest revision as of 11:08, 15 February 2025
GSK-4112[edit]
GSK-4112 is a synthetic chemical compound that acts as a selective ligand for the nuclear receptor Rev-ErbA alpha. It is primarily used in research to study the physiological roles of Rev-ErbA alpha, which is involved in the regulation of circadian rhythm, metabolism, and inflammation.
Mechanism of Action[edit]
GSK-4112 functions as an agonist of the Rev-ErbA alpha receptor. By binding to this receptor, GSK-4112 influences the transcription of genes involved in various biological processes. The activation of Rev-ErbA alpha by GSK-4112 leads to the repression of target genes, which can affect the circadian clock, lipid metabolism, and glucose homeostasis.
Biological Effects[edit]
The activation of Rev-ErbA alpha by GSK-4112 has been shown to have several biological effects:
- Circadian Rhythm Regulation: GSK-4112 can modulate the expression of core clock genes, thereby influencing the circadian rhythm.
- Metabolic Effects: It affects lipid and glucose metabolism, potentially offering insights into the treatment of metabolic disorders.
- Inflammation: GSK-4112 has been studied for its role in modulating inflammatory responses, which could have implications for diseases characterized by chronic inflammation.
Research Applications[edit]
GSK-4112 is used extensively in biomedical research to explore the functions of Rev-ErbA alpha. It serves as a tool compound to dissect the pathways regulated by this nuclear receptor and to understand its role in various physiological and pathological conditions.
