CBiPES

CBiPES is a chemical compound that is often used in scientific research. It is a cell-permeable inhibitor of TRIP-Br1, a transcriptional regulator implicated in cell cycle progression and apoptosis.

Chemical Structure

CBiPES has a molecular formula of C20H23N3O2S and a molecular weight of 365.48 g/mol. Its systematic name is N-(cyclohexylmethyl)-4-(2-phenylethynyl)benzenesulfonamide. The compound is typically available as a white to off-white powder.

Mechanism of Action

CBiPES acts by binding to the transcriptional regulator TRIP-Br1, thereby inhibiting its function. TRIP-Br1 is known to interact with various proteins involved in cell cycle progression and apoptosis, including cyclin E, CDK2, and p53. By inhibiting TRIP-Br1, CBiPES can affect these processes and potentially influence cell growth and survival.

Applications in Research

CBiPES has been used in various research studies to investigate the role of TRIP-Br1 in cell cycle regulation and apoptosis. For example, it has been used to study the effects of TRIP-Br1 inhibition on cancer cell growth and survival. In addition, CBiPES has been used to investigate the potential therapeutic applications of TRIP-Br1 inhibition in cancer treatment.

Safety and Handling

As with all chemical compounds, CBiPES should be handled with care. It should be stored in a cool, dry place and protected from light. Direct contact with the skin or eyes should be avoided, and appropriate personal protective equipment should be worn when handling this compound.

References

• TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Embo J. 2001 May 1;20(9):2273-85.
• A small molecule inhibitor of TRIP-Br1 down-regulates cyclin E and inhibits cancer cell proliferation. Cancer Lett. 2011 Jan 28;300(2):145-53.

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