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'''Chronaxie''' is a concept in [[electrophysiology]] that refers to the minimum time over which an electric current double the [[rheobase]] needs to be applied to a [[neuron]] or [[muscle fiber]] to trigger an action potential. It is a measure of the excitability or responsiveness of a nerve or muscle cell to electrical stimulation.
== Chronaxie ==


== History ==
[[File:Rheobase_chronaxie.svg|thumb|right|Diagram illustrating the relationship between rheobase and chronaxie.]]


The term "chronaxie" was first introduced by [[Louis Lapicque]] in 1907. Lapicque was a French [[physiologist]] who used the concept to describe the time required for an electrical stimulus of twice the threshold intensity to stimulate a nerve or muscle cell.
Chronaxie is a fundamental concept in the field of [[neurophysiology]] and [[electrophysiology]], describing the minimum time required for an electric current double the strength of the [[rheobase]] to stimulate a muscle or a neuron. It is a measure of the excitability of a nerve or muscle cell and is used to assess the functional state of these tissues.


== Measurement ==
== Definition ==


Chronaxie is measured in milliseconds (ms) and is used to determine the type of nerve or muscle fiber. For instance, the chronaxie for motor nerves is about 0.5 ms, sensory nerves about 0.2 ms, and pain fibers about 1 ms.  
Chronaxie is defined as the duration of time that a current, which is twice the intensity of the rheobase, must be applied to elicit a response from a nerve or muscle fiber. The rheobase is the minimum current amplitude with indefinite duration required to elicit a response. Chronaxie is typically measured in milliseconds.


== Clinical significance ==
== Historical Background ==


Chronaxie measurements can be used in the diagnosis and treatment of various [[neuromuscular disorders]]. For example, a prolonged chronaxie may indicate a [[neuropathy]] or [[myopathy]], while a shortened chronaxie may suggest a [[hyperexcitability disorder]] such as [[tetany]] or [[myotonia]].
The concept of chronaxie was introduced by the French physiologist [[Louis Lapicque]] in the early 20th century. Lapicque's work laid the foundation for understanding the electrical properties of excitable tissues and contributed significantly to the development of modern electrophysiology.


== See also ==
== Importance in Electrophysiology ==


Chronaxie is an important parameter in the study of nerve and muscle excitability. It provides insights into the physiological state of tissues and can be used to diagnose certain neuromuscular disorders. A change in chronaxie can indicate alterations in the excitability of nerve or muscle fibers, which may be due to pathological conditions.
== Measurement Techniques ==
Chronaxie is measured using a strength-duration curve, which plots the intensity of the current against the duration required to elicit a response. The point on the curve where the current is twice the rheobase is used to determine the chronaxie. This measurement is typically performed using specialized electrophysiological equipment.
== Applications ==
Chronaxie is used in various clinical and research settings. It is particularly useful in the field of [[neurology]] and [[rehabilitation medicine]] for assessing nerve and muscle function. It also plays a role in the development of [[neuroprosthetics]] and [[functional electrical stimulation]] devices.
== Related Concepts ==
* [[Rheobase]]
* [[Strength-duration curve]]
* [[Strength-duration curve]]
* [[Rheobase]]
* [[Excitability]]
* [[Electrophysiology]]
* [[Neurophysiology]]
* [[Neuromuscular junction]]


== References ==
== Related pages ==


{{reflist}}
* [[Electrophysiology]]
* [[Neurophysiology]]
* [[Muscle contraction]]


[[Category:Electrophysiology]]
[[Category:Electrophysiology]]
[[Category:Neurophysiology]]
[[Category:Neurophysiology]]
[[Category:Medical terminology]]
{{medicine-stub}}

Latest revision as of 10:56, 15 February 2025

Chronaxie[edit]

Diagram illustrating the relationship between rheobase and chronaxie.

Chronaxie is a fundamental concept in the field of neurophysiology and electrophysiology, describing the minimum time required for an electric current double the strength of the rheobase to stimulate a muscle or a neuron. It is a measure of the excitability of a nerve or muscle cell and is used to assess the functional state of these tissues.

Definition[edit]

Chronaxie is defined as the duration of time that a current, which is twice the intensity of the rheobase, must be applied to elicit a response from a nerve or muscle fiber. The rheobase is the minimum current amplitude with indefinite duration required to elicit a response. Chronaxie is typically measured in milliseconds.

Historical Background[edit]

The concept of chronaxie was introduced by the French physiologist Louis Lapicque in the early 20th century. Lapicque's work laid the foundation for understanding the electrical properties of excitable tissues and contributed significantly to the development of modern electrophysiology.

Importance in Electrophysiology[edit]

Chronaxie is an important parameter in the study of nerve and muscle excitability. It provides insights into the physiological state of tissues and can be used to diagnose certain neuromuscular disorders. A change in chronaxie can indicate alterations in the excitability of nerve or muscle fibers, which may be due to pathological conditions.

Measurement Techniques[edit]

Chronaxie is measured using a strength-duration curve, which plots the intensity of the current against the duration required to elicit a response. The point on the curve where the current is twice the rheobase is used to determine the chronaxie. This measurement is typically performed using specialized electrophysiological equipment.

Applications[edit]

Chronaxie is used in various clinical and research settings. It is particularly useful in the field of neurology and rehabilitation medicine for assessing nerve and muscle function. It also plays a role in the development of neuroprosthetics and functional electrical stimulation devices.

Related Concepts[edit]

Related pages[edit]