OR1N2: Difference between revisions

OR1N2
Symbol	OR1N2
HGNC ID	8191
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	9q33
Locus supplementary data	–

Latest revision as of 20:37, 30 December 2024

OR1N2 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are responsible for the detection of odor molecules and are a part of the G protein-coupled receptor (GPCR) superfamily.

Function[edit]

Olfactory receptors, such as OR1N2, interact with odorant molecules in the olfactory epithelium to initiate a neuronal response that results in the perception of a smell. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is a common feature of many neurotransmitter and hormone receptors.

The OR1N2 gene is one of the many olfactory receptor genes located on chromosome 9. These genes are responsible for the recognition and G protein-mediated transduction of odorant signals.

Gene Family[edit]

The olfactory receptor gene family is the largest in the human genome. The nomenclature for these genes and proteins is independent of other organisms.

Clinical Significance[edit]

While the primary function of OR1N2 is related to the sense of smell, variations in olfactory receptor genes can influence individual differences in odor perception. However, specific clinical conditions directly associated with OR1N2 have not been extensively documented.

Research[edit]

Research into olfactory receptors like OR1N2 continues to provide insights into the mechanisms of smell and the potential for olfactory receptors to be involved in other physiological processes.

References[edit]

External Links[edit]

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-'''OR1N2''' is a gene that encodes the olfactory receptor, family 1, subfamily N, member 2 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.
-== Function ==
+{{Infobox gene
+| name = OR1N2
+| symbol = OR1N2
+| HGNCid = 8191
+| chromosome = 9
+| arm = q
+| band = 33
+}}
-The OR1N2 gene is part of the [[olfactory receptor]] gene family, which is the largest gene family in the human genome. The proteins encoded by these genes are responsible for the recognition and transduction of odorant signals, which are mediated by G proteins. This gene family is highly polymorphic and diverse, with each gene encoding a unique receptor that can recognize a specific odorant molecule.
+'''OR1N2''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are responsible for the detection of odor molecules and are a part of the [[G protein-coupled receptor]] (GPCR) superfamily.
-== Structure ==
+==Function==
+Olfactory receptors, such as OR1N2, interact with odorant molecules in the [[olfactory epithelium]] to initiate a neuronal response that results in the perception of a smell. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is a common feature of many neurotransmitter and hormone receptors.
-The OR1N2 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2, from base pair 156,104,297 to base pair 156,105,487. The gene is composed of a single coding exon. The protein encoded by this gene shares a 7-transmembrane domain structure with many neurotransmitter and hormone receptors.
+The OR1N2 gene is one of the many olfactory receptor genes located on [[chromosome 9]]. These genes are responsible for the recognition and G protein-mediated transduction of odorant signals.
-== Clinical Significance ==
+==Gene Family==
+The olfactory receptor gene family is the largest in the human genome. The nomenclature for these genes and proteins is independent of other organisms.
-While the specific clinical significance of OR1N2 is not yet fully understood, the olfactory receptor gene family as a whole has been implicated in a variety of diseases, including [[anosmia]] (loss of the sense of smell), and [[olfactory neuroblastoma]] (a rare type of cancer that starts in the olfactory nerve).
+==Clinical Significance==
+While the primary function of OR1N2 is related to the sense of smell, variations in olfactory receptor genes can influence individual differences in odor perception. However, specific clinical conditions directly associated with OR1N2 have not been extensively documented.
-[[File:OR1N2 gene location on human chromosome 1.png|thumb|right|300px|Location of the OR1N2 gene on human chromosome 1.]]
+==Research==
+Research into olfactory receptors like OR1N2 continues to provide insights into the mechanisms of smell and the potential for olfactory receptors to be involved in other physiological processes.
-== See Also ==
+==See Also==
+* [[Olfactory system]]
-* [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Anosmia]]
+* [[Chromosome 9 (human)]]
-* [[Olfactory neuroblastoma]]
-== References ==
+==References==
+{{Reflist}}
-<references />
+==External Links==
+* [https://www.ncbi.nlm.nih.gov/gene/OR1N2 OR1N2 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR1N2 OR1N2 Gene - GeneCards]
-[[Category:Genes on human chromosome 1]]
+[[Category:Olfactory receptors]]
-[[Category:Olfactory system]]
 [[Category:G protein-coupled receptors]]
+[[Category:Genes on human chromosome 9]]
-{{G protein-coupled receptors}}
-{{Olfactory receptors}}
-{{medicine-stub}}