ID3 (gene): Difference between revisions

ID3
Symbol	ID3
HGNC ID	6037
Alternative symbols	–
Entrez Gene	3399
OMIM	600277
RefSeq	NM_002167
UniProt	Q02535
Chromosome	1p36.12
Locus supplementary data	–

Latest revision as of 04:24, 29 December 2024

ID3 (Inhibitor of DNA Binding 3) is a protein that in humans is encoded by the ID3 gene. The ID3 gene is a member of the ID gene family, which is involved in the regulation of cell growth, differentiation, and development.

Function[edit]

The ID3 protein is a member of the helix-loop-helix (HLH) family of transcription factors. It acts as a dominant negative regulator of basic HLH transcription factors by forming non-functional heterodimers. This prevents the binding of these transcription factors to E-box sequences in the DNA, thereby inhibiting their ability to regulate gene expression.

ID3 plays a crucial role in various biological processes, including neurogenesis, angiogenesis, and the immune response. It is also involved in the regulation of the cell cycle and can influence cell proliferation and apoptosis.

Clinical Significance[edit]

Alterations in the expression of ID3 have been associated with several types of cancer, including breast cancer, prostate cancer, and lymphoma. Overexpression of ID3 can lead to increased cell proliferation and tumorigenesis, while loss of ID3 function can result in impaired cell growth and differentiation.

Research has shown that ID3 may play a role in the development of cardiovascular disease and metabolic disorders. It is also being studied as a potential target for therapeutic intervention in various diseases.

Interactions[edit]

ID3 interacts with several other proteins, including members of the E protein family, such as E2A, HEB, and E2-2. These interactions are important for the regulation of gene expression and the maintenance of cellular homeostasis.

References[edit]

External Links[edit]

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-'''ID3 (gene)'''
-The '''ID3 (gene)''' or '''Inhibitor of DNA Binding 3''' is a [[gene]] that encodes a member of the [[inhibitor of DNA binding]] (ID) protein family. These proteins are basic [[helix-loop-helix]] (bHLH) transcription factors which can form heterodimers with other bHLH proteins. The encoded protein is believed to play a role in [[cell cycle]] progression by inhibiting the cellular differentiation process.
+{{Infobox gene
+| name = ID3
+| symbol = ID3
+| HGNCid = 6037
+| OMIM = 600277
+| EntrezGene = 3399
+| RefSeq = NM_002167
+| UniProt = Q02535
+| chromosome = 1
+| arm = p
+| band = 36.12
+}}
-[[File:ID3 gene location on human chromosome 1.png|thumb|Location of ID3 gene on human chromosome 1]]
+'''ID3''' (Inhibitor of DNA Binding 3) is a protein that in humans is encoded by the '''ID3 gene'''. The ID3 gene is a member of the [[ID (gene family)|ID gene family]], which is involved in the regulation of cell growth, differentiation, and development.
 == Function ==
+The ID3 protein is a member of the [[helix-loop-helix]] (HLH) family of transcription factors. It acts as a dominant negative regulator of basic HLH transcription factors by forming non-functional heterodimers. This prevents the binding of these transcription factors to [[E-box]] sequences in the DNA, thereby inhibiting their ability to regulate gene expression.
-The ID3 gene is a member of the ID family, which includes four different proteins: ID1, ID2, ID3, and ID4. These proteins are involved in various cellular processes, including [[cell proliferation]], [[cell differentiation]], and [[apoptosis]]. They function by binding to other bHLH transcription factors, preventing them from binding to DNA and activating gene expression. This inhibitory action is critical for the control of cell growth and differentiation.
+ID3 plays a crucial role in various biological processes, including [[neurogenesis]], [[angiogenesis]], and the [[immune response]]. It is also involved in the regulation of the [[cell cycle]] and can influence [[cell proliferation]] and [[apoptosis]].
-== Clinical significance ==
+== Clinical Significance ==
+Alterations in the expression of ID3 have been associated with several types of [[cancer]], including [[breast cancer]], [[prostate cancer]], and [[lymphoma]]. Overexpression of ID3 can lead to increased cell proliferation and tumorigenesis, while loss of ID3 function can result in impaired cell growth and differentiation.
-Mutations in the ID3 gene have been associated with several types of [[cancer]], including [[leukemia]], [[lymphoma]], and [[glioblastoma]]. These mutations often result in the overexpression of the ID3 protein, leading to uncontrolled cell growth and proliferation. In addition, ID3 has been implicated in the development of [[cardiovascular disease]], as it plays a role in the regulation of [[vascular smooth muscle]] cell proliferation and differentiation.
+Research has shown that ID3 may play a role in the development of [[cardiovascular disease]] and [[metabolic disorders]]. It is also being studied as a potential target for therapeutic intervention in various diseases.
-== See also ==
+== Interactions ==
+ID3 interacts with several other proteins, including members of the [[E protein]] family, such as [[E2A]], [[HEB]], and [[E2-2]]. These interactions are important for the regulation of gene expression and the maintenance of cellular homeostasis.
-* [[Inhibitor of DNA binding]]
+== See Also ==
-* [[Helix-loop-helix]]
+* [[ID1 (gene)]]
-* [[Transcription factor]]
+* [[ID2 (gene)]]
-* [[Cell cycle]]
+* [[ID4 (gene)]]
-* [[Cell differentiation]]
 == References ==
+{{Reflist}}
-<references />
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/3399 ID3 Gene - NCBI]
+* [https://www.uniprot.org/uniprot/Q02535 ID3 Protein - UniProt]
-[[Category:Genes]]
+[[Category:Genes on human chromosome 1]]
-[[Category:Human proteins]]
 [[Category:Transcription factors]]
-{{medicine-stub}}
+[[Category:Helix-loop-helix proteins]]
+[[Category:Cancer research]]