OR10V1

OR10V1 is a protein that in humans is encoded by the OR10V1 gene. The protein is a member of the olfactory receptor family, which is involved in the detection of smell.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

Gene

The OR10V1 gene is located on chromosome 1, specifically at 1q44. It spans approximately 1.1 kilobases and consists of a single coding exon. The gene is expressed in the olfactory epithelium, the tissue lining the nasal cavity that is involved in smell.

Clinical significance

While the exact role of OR10V1 in disease is not fully understood, variations in the gene have been associated with differences in the perception of smell. This could potentially have implications for conditions such as anosmia (loss of the sense of smell), hyposmia (reduced ability to smell), and parosmia (changes in the perception of smells).

See also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Hyposmia
• Parosmia

References

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