OR52L1

OR52L1 is a gene that encodes a protein in the olfactory receptor family. This family is a group of G protein-coupled receptors which are responsible for detecting molecules in the environment and subsequently initiating a neuronal response. The olfactory receptor proteins interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

Function

The olfactory receptor family is the largest in the genome. The family members of OR52L1 are located in a cluster on chromosome 11. The specific function of this protein, like many in the olfactory receptor family, is unknown. However, it is thought to play a role in the detection of odorants.

Structure

The OR52L1 gene is located on chromosome 11, specifically at 11p15.4. It spans approximately 1.1 kilobases and contains one exon. The encoded protein is a member of the olfactory receptor family, and like other members of this family, it is a G protein-coupled receptor.

Clinical Significance

While the specific function of OR52L1 is not well understood, it is thought to play a role in the detection of odorants. Mutations in this gene, as well as other genes in the olfactory receptor family, have been associated with a decreased sense of smell, known as anosmia.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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