OR10H3

OR10H3 is a gene that encodes a protein in the olfactory receptor family. This family is responsible for the detection of odorants in organisms. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

Function

Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

Gene

The OR10H3 gene is located on chromosome 1, specifically on the long (q) arm at position 23.2, from base pair 150,726,218 to base pair 150,727,219.

Clinical Significance

While the specific clinical significance of OR10H3 is not yet fully understood, olfactory receptors in general have been linked to various diseases. For example, mutations in olfactory receptors have been associated with a decreased sense of smell, known as anosmia.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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