Progastricsin: Difference between revisions

Latest revision as of 20:33, 30 December 2024

Progastricsin (also known as pepsinogen C) is a zymogen secreted by the gastric chief cells in the stomach. It is an aspartic protease that is activated to its active form, pepsin, in the acidic environment of the stomach.

Function[edit]

Progastricsin is involved in the digestion of proteins in the stomach. It is secreted as an inactive precursor, which is then converted into the active enzyme pepsin by the acidic pH of the stomach. This conversion involves the cleavage of a peptide bond in the progastricsin molecule, resulting in the active enzyme.

Clinical significance[edit]

Elevated levels of progastricsin in the blood can be indicative of certain gastric diseases, such as gastritis or gastric cancer. It is often measured in conjunction with other biomarkers to assess gastric function and health.

References[edit]

External links[edit]

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-'''Progastricsin''' is a [[protein]] that in humans is encoded by the [[PGC]] gene. It is also known as [[pepsinogen C]] and is a member of the [[pepsinogen]] family. This protein is an [[enzyme]] precursor that is secreted by the [[stomach]] lining and, when activated in the stomach, breaks down dietary proteins into [[peptides]].
-== Function ==
+{{Infobox protein
+| name = Progastricsin
+| image = <!-- Image removed -->
+| caption = <!-- Image caption -->
+| symbol = PGC
+| HGNCid = 8888
+| OMIM = 169720
+| RefSeq = NM_002630
+| UniProt = P20142
+}}
-[[Progastricsin]] is an aspartic proteinase that is expressed in the [[stomach]] mucosa. It is an [[enzyme]] precursor that is activated in the acidic environment of the stomach to form [[pepsin C]], which breaks down dietary proteins into [[peptides]]. The exact role of progastricsin in the stomach is not fully understood, but it is believed to play a role in the initial stages of protein digestion.
+'''Progastricsin''' (also known as '''pepsinogen C''') is a [[zymogen]] secreted by the [[gastric chief cell]]s in the [[stomach]]. It is an [[aspartic protease]] that is activated to its active form, [[pepsin]], in the acidic environment of the stomach.
-== Structure ==
+== Function ==
+Progastricsin is involved in the [[digestion]] of proteins in the stomach. It is secreted as an inactive precursor, which is then converted into the active enzyme pepsin by the acidic pH of the stomach. This conversion involves the cleavage of a peptide bond in the progastricsin molecule, resulting in the active enzyme.
-The [[PGC]] gene that encodes progastricsin is located on the short (p) arm of [[chromosome 6]] at position 21. The protein itself is composed of 388 [[amino acids]] and has a molecular weight of approximately 42 kDa.
 == Clinical significance ==
+Elevated levels of progastricsin in the [[blood]] can be indicative of certain [[gastric diseases]], such as [[gastritis]] or [[gastric cancer]]. It is often measured in conjunction with other [[biomarkers]] to assess gastric function and health.
-Alterations in the [[PGC]] gene have been associated with [[gastric cancer]], one of the leading causes of cancer-related deaths worldwide. Studies have shown that lower levels of progastricsin expression may be associated with a higher risk of gastric cancer.
-[[File:Progastricsin 3D structure.jpg|thumb|right|3D structure of progastricsin]]
 == See also ==
 * [[Pepsinogen]]
-* [[Pepsin]]
 * [[Gastric acid]]
-* [[Stomach cancer]]
+* [[Digestive enzyme]]
 == References ==
+{{Reflist}}
-{{Reflist}}
+== External links ==
+* [https://www.uniprot.org/uniprot/P20142 UniProt entry for Progastricsin]
+* [https://www.ncbi.nlm.nih.gov/gene/5225 NCBI Gene entry for PGC]
-[[Category:Human proteins]]
+[[Category:Proteins]]
-[[Category:Digestive enzymes]]
+[[Category:Digestive system]]
-[[Category:Genes on human chromosome 6]]
+[[Category:Enzymes]]
 [[Category:Stomach]]
-{{medicine-stub}}