ELAV-like protein 1: Difference between revisions

Latest revision as of 21:17, 27 December 2024

ELAV-like protein 1 (also known as HuR) is a member of the ELAV family of RNA-binding proteins. It is encoded by the ELAVL1 gene in humans. This protein is involved in the regulation of mRNA stability and translation, playing a crucial role in the post-transcriptional regulation of gene expression.

Function[edit]

ELAV-like protein 1 binds to AU-rich elements (AREs) in the 3' untranslated regions (UTRs) of target mRNAs. This binding stabilizes the mRNA and prevents its degradation, thereby influencing the expression of genes involved in cell cycle, apoptosis, and immune response.

Clinical Significance[edit]

Alterations in the expression or function of ELAV-like protein 1 have been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. Overexpression of HuR has been observed in several types of cancer, where it is associated with increased tumor growth and poor prognosis.

Interactions[edit]

ELAV-like protein 1 interacts with a variety of other proteins and RNA molecules. It is known to interact with hnRNP proteins, microRNAs, and components of the RNA-induced silencing complex (RISC), modulating their activity and function.

Research[edit]

Research on ELAV-like protein 1 is ongoing, with studies focusing on its role in gene regulation, its potential as a biomarker for disease, and its viability as a target for therapeutic intervention.

References[edit]

External Links[edit]

[ELAVL1 gene information at NCBI](https://www.ncbi.nlm.nih.gov/gene/1994)
[UniProt entry for ELAV-like protein 1](https://www.uniprot.org/uniprot/Q15717)

   This article is a protein-related stub. You can help WikiMD by expanding it!

@@ Line 1: / Line 1: @@
-'''ELAV-like protein 1''' (also known as '''HuR''' or '''Hu antigen R''') is a protein that in humans is encoded by the '''ELAVL1''' gene. It is a member of the [[ELAV family]] of RNA-binding proteins which contain three RNA recognition motifs (RRMs) and bind AU-rich elements (AREs) in [[mRNA]].
+{{Infobox protein
+| name = ELAV-like protein 1
+| image = <!-- Image removed -->
+| caption = <!-- Caption removed -->
+| symbol = ELAVL1
+| alt_symbols = HuR
+| hgnc_id = 3316
+| omim_id = 600597
+| uniprot_id = Q15717
+| chromosomal_location = 19p13.2
+}}
+'''ELAV-like protein 1''' (also known as '''HuR''') is a member of the [[ELAV family]] of RNA-binding proteins. It is encoded by the '''ELAVL1''' gene in humans. This protein is involved in the regulation of [[mRNA]] stability and translation, playing a crucial role in the post-transcriptional regulation of gene expression.
 == Function ==
-ELAV-like protein 1 is involved in the regulation of [[RNA stability]] and [[translation]], playing a crucial role in post-transcriptional gene regulation. It binds to and stabilizes mRNAs such as those containing AREs found in the 3' untranslated regions of many proto-oncogenes and [[cytokine]] genes. The protein is also involved in the regulation of [[cell proliferation]], [[cell differentiation]], and [[cell death]].
+ELAV-like protein 1 binds to [[AU-rich elements]] (AREs) in the 3' [[untranslated regions]] (UTRs) of target mRNAs. This binding stabilizes the mRNA and prevents its degradation, thereby influencing the expression of genes involved in [[cell cycle]], [[apoptosis]], and [[immune response]].
-== Clinical significance ==
+== Clinical Significance ==
-Alterations in the function of ELAV-like protein 1 have been associated with various diseases, including [[cancer]], [[neurodegenerative diseases]], and [[autoimmune diseases]]. In cancer, overexpression of the protein has been observed and is associated with increased [[tumor]] growth and progression. In neurodegenerative diseases, the protein is thought to play a role in the selective vulnerability of neurons.
+Alterations in the expression or function of ELAV-like protein 1 have been implicated in various [[diseases]], including [[cancer]], [[neurodegenerative disorders]], and [[inflammatory diseases]]. Overexpression of HuR has been observed in several types of cancer, where it is associated with increased tumor growth and poor prognosis.
-== Structure ==
+== Interactions ==
-The ELAVL1 gene is located on the short (p) arm of [[chromosome 19]] at position 13.2. The protein encoded by this gene is approximately 36 kDa in size and contains three RRMs.
+ELAV-like protein 1 interacts with a variety of other proteins and RNA molecules. It is known to interact with [[hnRNP]] proteins, [[microRNAs]], and components of the [[RNA-induced silencing complex]] (RISC), modulating their activity and function.
 == Research ==
-Research into ELAV-like protein 1 is ongoing, with studies focusing on its role in disease progression and potential as a therapeutic target.
+Research on ELAV-like protein 1 is ongoing, with studies focusing on its role in [[gene regulation]], its potential as a [[biomarker]] for disease, and its viability as a target for therapeutic intervention.
-[[File:ELAVL1 protein structure.jpg|thumb|right|300px|Structure of the ELAVL1 protein.]]
+== See Also ==
+* [[RNA-binding protein]]
+* [[Post-transcriptional regulation]]
+* [[Gene expression]]
-== See also ==
+== References ==
-* [[ELAVL2]]
+<references/>
-* [[ELAVL3]]
-* [[ELAVL4]]
-== References ==
+== External Links ==
-<references />
+* [ELAVL1 gene information at NCBI](https://www.ncbi.nlm.nih.gov/gene/1994)
+* [UniProt entry for ELAV-like protein 1](https://www.uniprot.org/uniprot/Q15717)
-== External links ==
+{{Protein-stub}}
-* [http://www.genecards.org/cgi-bin/carddisp.pl?gene=ELAVL1 GeneCards - ELAVL1]
 [[Category:RNA-binding proteins]]
+[[Category:Human proteins]]
 [[Category:Gene expression]]
-[[Category:Human proteins]]
+[[Category:Post-transcriptional regulation]]
-[[Category:Chromosome 19 gene stubs]]
-{{Chromosome 19 gene stub}}
-{{medicine-stub}}