EHF (gene)

EHF (gene)

The EHF gene, also known as ETS homologous factor, is a gene that is located on the 11th chromosome in humans. It is a member of the ETS family of transcription factors and is involved in a variety of functions including cellular development, cell proliferation, and apoptosis.<ref>,

 Genomic and biochemical insights into the specificity of ETS transcription factors, 
 Annual Review of Biochemistry, 
 2011,
 Vol. 80,
 pp. 437–71,
 DOI: 10.1146/annurev.biochem.79.081507.103945,
 PMID: 21456944,</ref>

Function

The EHF gene encodes a protein that functions as a transcriptional repressor and has been shown to downregulate the expression of genes involved in cell growth and proliferation. It is also involved in the regulation of epithelial cell differentiation and has been implicated in the development of prostate cancer and asthma.<ref>,

 Defining ETS transcription regulatory networks and their contribution to breast cancer progression, 
 Journal of Cellular Biochemistry, 
 2007,
 Vol. 102(Issue: 3),
 pp. 549–59,
 DOI: 10.1002/jcb.21287,
 PMID: 17226767,</ref>

Clinical significance

Mutations in the EHF gene have been associated with a variety of diseases. For example, a mutation in this gene has been linked to an increased risk of prostate cancer. Additionally, variations in the EHF gene have been associated with susceptibility to asthma and other respiratory diseases.<ref>,

 Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population, 
 Nature Genetics, 
 2012,
 Vol. 44(Issue: 12),
 pp. 1222–6,
 DOI: 10.1038/ng.2438,
 PMID: 23104006,</ref>

See also

• ETS family
• Transcription factor
• Prostate cancer
• Asthma

References

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