Spilanthol: Difference between revisions

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'''Spilanthol''' is an [[alkamide]] found in the [[Acmella oleracea]] plant, also known as the "toothache plant" or "paracress". It is a bioactive compound that has been studied for its various potential therapeutic applications.
{{Short description|A natural compound with anesthetic and anti-inflammatory properties}}
{{Use dmy dates|date=October 2023}}


==Chemistry==
==Spilanthol==
Spilanthol is a [[fatty acid amide]] derivative, specifically an [[N-isobutylamide]]. It is a lipophilic compound, meaning it is soluble in fats and oils but not in water. Its chemical structure includes a 15-carbon chain with a [[amide]] group at one end.
[[File:Spilanthol_skeletal.svg|thumb|right|Skeletal structure of Spilanthol]]
'''Spilanthol''' is a natural compound found in various plants, most notably in the [[Acmella oleracea]], commonly known as the toothache plant. It is known for its anesthetic and anti-inflammatory properties, making it a subject of interest in both traditional and modern medicine.


==Pharmacology==
==Chemical Structure==
Spilanthol has been found to have several pharmacological effects. It is most well-known for its local [[anesthetic]] effects, which is why Acmella oleracea is often used in traditional medicine for toothache. It works by blocking [[sodium channels]] in nerve cells, preventing the transmission of pain signals.
Spilanthol is an unsaturated fatty acid amide. Its chemical structure consists of a long carbon chain with a terminal amide group. The presence of double bonds in the carbon chain contributes to its biological activity. The molecular formula of spilanthol is C<sub>14</sub>H<sub>23</sub>NO.


In addition to its anesthetic effects, spilanthol has also been found to have [[antimicrobial]], [[antifungal]], [[antioxidant]], and [[anti-inflammatory]] properties. It has been studied for potential use in treating a variety of conditions, from skin diseases to digestive disorders.
==Sources==
Spilanthol is primarily extracted from the [[Acmella oleracea]] plant, which is native to the tropical regions of South America. The plant is characterized by its small, yellow flowers and is often used in traditional medicine for its analgesic properties.


==Potential Therapeutic Applications==
==Biological Activity==
Research into the potential therapeutic applications of spilanthol is ongoing. Some studies have suggested that it may be useful in treating [[periodontal disease]], due to its antimicrobial and anti-inflammatory effects. Other research has looked at its potential use in skin care products, due to its antioxidant properties and its ability to stimulate the production of [[collagen]].
Spilanthol exhibits several biological activities:


==Safety==
* '''Anesthetic Properties''': It acts as a local anesthetic, providing relief from pain when applied topically. This property is particularly useful in dental applications, where it can be used to alleviate toothache.
While spilanthol is generally considered safe for topical use, it can cause a tingling or numbing sensation. Oral consumption of spilanthol, such as in herbal teas made from Acmella oleracea, is also generally considered safe, although it can cause a similar numbing sensation in the mouth and throat.


==See Also==
* '''Anti-inflammatory Effects''': Spilanthol has been shown to reduce inflammation, making it beneficial in treating conditions associated with inflammatory responses.
 
* '''Antimicrobial Activity''': It also possesses antimicrobial properties, which can help in preventing infections.
 
==Applications==
Due to its anesthetic and anti-inflammatory properties, spilanthol is used in various applications:
 
* '''Traditional Medicine''': In traditional medicine, spilanthol is used to treat toothaches, sore throats, and other minor ailments.
 
* '''Cosmetics''': It is incorporated into cosmetic products for its ability to smooth and firm the skin, providing a "tingling" sensation that is often described as refreshing.
 
* '''Pharmaceuticals''': Research is ongoing to explore its potential in developing new pharmaceutical products for pain relief and inflammation.
 
==Safety and Toxicity==
Spilanthol is generally considered safe when used in appropriate amounts. However, excessive use can lead to irritation or allergic reactions in some individuals. It is important to conduct further studies to fully understand its safety profile.
 
==Related pages==
* [[Acmella oleracea]]
* [[Acmella oleracea]]
* [[Alkamide]]
* [[Anesthetic]]
* [[Anesthetic]]
* [[Antimicrobial]]
* [[Anti-inflammatory]]
* [[Anti-inflammatory]]
* [[Traditional medicine]]


==References==
[[Category:Natural compounds]]
<references />
 
[[Category:Pharmacology]]
[[Category:Bioactive compounds]]
[[Category:Medicinal plants]]
[[Category:Anesthetics]]
[[Category:Anesthetics]]
[[Category:Antimicrobials]]
[[Category:Anti-inflammatory agents]]
[[Category:Anti-inflammatories]]
 
{{pharmacology-stub}}

Latest revision as of 10:59, 15 February 2025

A natural compound with anesthetic and anti-inflammatory properties



Spilanthol[edit]

Skeletal structure of Spilanthol

Spilanthol is a natural compound found in various plants, most notably in the Acmella oleracea, commonly known as the toothache plant. It is known for its anesthetic and anti-inflammatory properties, making it a subject of interest in both traditional and modern medicine.

Chemical Structure[edit]

Spilanthol is an unsaturated fatty acid amide. Its chemical structure consists of a long carbon chain with a terminal amide group. The presence of double bonds in the carbon chain contributes to its biological activity. The molecular formula of spilanthol is C14H23NO.

Sources[edit]

Spilanthol is primarily extracted from the Acmella oleracea plant, which is native to the tropical regions of South America. The plant is characterized by its small, yellow flowers and is often used in traditional medicine for its analgesic properties.

Biological Activity[edit]

Spilanthol exhibits several biological activities:

  • Anesthetic Properties: It acts as a local anesthetic, providing relief from pain when applied topically. This property is particularly useful in dental applications, where it can be used to alleviate toothache.
  • Anti-inflammatory Effects: Spilanthol has been shown to reduce inflammation, making it beneficial in treating conditions associated with inflammatory responses.
  • Antimicrobial Activity: It also possesses antimicrobial properties, which can help in preventing infections.

Applications[edit]

Due to its anesthetic and anti-inflammatory properties, spilanthol is used in various applications:

  • Traditional Medicine: In traditional medicine, spilanthol is used to treat toothaches, sore throats, and other minor ailments.
  • Cosmetics: It is incorporated into cosmetic products for its ability to smooth and firm the skin, providing a "tingling" sensation that is often described as refreshing.
  • Pharmaceuticals: Research is ongoing to explore its potential in developing new pharmaceutical products for pain relief and inflammation.

Safety and Toxicity[edit]

Spilanthol is generally considered safe when used in appropriate amounts. However, excessive use can lead to irritation or allergic reactions in some individuals. It is important to conduct further studies to fully understand its safety profile.

Related pages[edit]