ERG5

ERG5 is a gene that encodes for the enzyme sterol C-22 desaturase in Saccharomyces cerevisiae, commonly known as baker's yeast. This enzyme is a crucial component in the biosynthesis of ergosterol, a sterol that is vital for the proper functioning and structure of yeast cell membranes.

Function

The ERG5 gene is responsible for the production of the enzyme sterol C-22 desaturase. This enzyme catalyzes the desaturation of zymosterol at the C-22 position, a critical step in the biosynthesis of ergosterol. Ergosterol is an essential sterol in yeast, playing a similar role to cholesterol in mammalian cells. It is crucial for maintaining the fluidity and integrity of the yeast cell membrane.

Clinical Significance

The ERG5 gene and its product, sterol C-22 desaturase, have been implicated in antifungal resistance. Some antifungal drugs, such as azoles, target the ergosterol biosynthesis pathway to inhibit the growth of fungal cells. Mutations in the ERG5 gene can lead to changes in the structure of sterol C-22 desaturase, potentially reducing the effectiveness of these drugs.

See Also

• ERG (gene)
• Ergosterol
• Saccharomyces cerevisiae

References

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