Videx: Difference between revisions

Latest revision as of 03:26, 13 February 2025

Didanosine[edit]

Chemical structure of Didanosine

Didanosine, also known by its brand name Videx, is an antiretroviral drug used in the treatment of HIV/AIDS. It is classified as a nucleoside reverse transcriptase inhibitor (NRTI), which works by inhibiting the action of reverse transcriptase, an enzyme crucial for the replication of HIV.

Mechanism of Action[edit]

Didanosine is a synthetic purine nucleoside analogue of deoxyadenosine. Once inside the body, it is converted to its active form, dideoxyadenosine triphosphate (ddATP). This active form competes with the natural substrate, deoxyadenosine triphosphate, for incorporation into the viral DNA by reverse transcriptase. The incorporation of ddATP into the viral DNA chain results in chain termination, thereby inhibiting viral replication.

Clinical Use[edit]

Didanosine is used in combination with other antiretroviral agents for the treatment of HIV infection. It is not recommended as monotherapy due to the rapid development of resistance. The drug is available in various formulations, including tablets and powder for oral solution.

Side Effects[edit]

Common side effects of didanosine include:

Serious side effects may include lactic acidosis and severe hepatomegaly with steatosis, which can be fatal.

Pharmacokinetics[edit]

Didanosine is rapidly absorbed after oral administration, but its bioavailability is reduced by the presence of food. It is therefore recommended to be taken on an empty stomach. The drug is primarily eliminated by the kidneys, and dose adjustments may be necessary in patients with renal impairment.

History[edit]

Didanosine was developed in the late 1980s and was one of the first antiretroviral drugs approved for the treatment of HIV. It was approved by the Food and Drug Administration (FDA) in 1991.

Related pages[edit]

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-'''Videx''' is a brand name for the antiretroviral medication [[Didanosine]], which is used in the treatment of [[Human Immunodeficiency Virus]] (HIV) infection. It is a type of medication known as a [[nucleoside reverse transcriptase inhibitor]] (NRTI), which works by blocking the action of an enzyme called reverse transcriptase, thereby preventing the virus from multiplying in the body.
+{{DISPLAYTITLE:Didanosine}}
-==History==
+== Didanosine ==
-Videx was developed by [[Bristol-Myers Squibb]], a global biopharmaceutical company. It was approved by the [[Food and Drug Administration]] (FDA) in the United States in 1991, making it one of the first antiretroviral medications available for the treatment of HIV.
-==Usage==
+[[File:Videx.svg|thumb|right|Chemical structure of Didanosine]]
-Videx is used in combination with other antiretroviral medications to treat HIV. It is not a cure for HIV or [[AIDS]], but it can help to control the virus and slow the progression of the disease. Videx is taken orally, usually once or twice a day.
-==Side Effects==
+'''Didanosine''', also known by its brand name '''Videx''', is an [[antiretroviral drug]] used in the treatment of [[HIV/AIDS]]. It is classified as a [[nucleoside reverse transcriptase inhibitor]] (NRTI), which works by inhibiting the action of reverse transcriptase, an enzyme crucial for the replication of [[HIV]].
-Like all medications, Videx can cause side effects. Common side effects include nausea, vomiting, diarrhea, and abdominal pain. More serious side effects can include pancreatitis, liver problems, and a rare but serious condition called [[lactic acidosis]].
-==Interactions==
+== Mechanism of Action ==
-Videx can interact with other medications, which can affect how it works or increase the risk of side effects. It is important to tell your doctor about all the medications you are taking, including prescription and over-the-counter medications, vitamins, and herbal supplements.
+Didanosine is a synthetic purine nucleoside analogue of [[deoxyadenosine]]. Once inside the body, it is converted to its active form, dideoxyadenosine triphosphate (ddATP). This active form competes with the natural substrate, deoxyadenosine triphosphate, for incorporation into the viral DNA by reverse transcriptase. The incorporation of ddATP into the viral DNA chain results in chain termination, thereby inhibiting viral replication.
+== Clinical Use ==
+Didanosine is used in combination with other antiretroviral agents for the treatment of [[HIV infection]]. It is not recommended as monotherapy due to the rapid development of resistance. The drug is available in various formulations, including tablets and powder for oral solution.
+== Side Effects ==
+Common side effects of didanosine include:
+* [[Peripheral neuropathy]]
+* [[Pancreatitis]]
+* [[Diarrhea]]
+* [[Nausea]]
+* [[Rash]]
+Serious side effects may include lactic acidosis and severe hepatomegaly with steatosis, which can be fatal.
+== Pharmacokinetics ==
+Didanosine is rapidly absorbed after oral administration, but its bioavailability is reduced by the presence of food. It is therefore recommended to be taken on an empty stomach. The drug is primarily eliminated by the kidneys, and dose adjustments may be necessary in patients with renal impairment.
+== History ==
+Didanosine was developed in the late 1980s and was one of the first antiretroviral drugs approved for the treatment of HIV. It was approved by the [[Food and Drug Administration]] (FDA) in 1991.
+== Related pages ==
-==See Also==
-* [[Antiretroviral therapy]]
 * [[HIV/AIDS]]
-* [[Nucleoside reverse transcriptase inhibitors]]
+* [[Antiretroviral drug]]
+* [[Nucleoside reverse transcriptase inhibitor]]
+* [[Zidovudine]]
 [[Category:Antiretroviral drugs]]
-[[Category:HIV/AIDS]]
+[[Category:HIV/AIDS treatment]]
-[[Category:Pharmaceuticals]]
-{{Medicine-stub}}
-{{Pharma-stub}}