Revision as of 01:55, 17 February 2025

PCPr is a synthetic compound that is used in scientific research. It is a potent and selective agonist for the peripheral cannabinoid receptor (CB2), with a Ki of 5.2 nM at CB2 and 1000 nM at the related CB1 receptor. This makes it around 200x selective for peripheral cannabinoid receptors. It has analgesic effects in animal studies, particularly against "atypical" pain stimuli, and has also been used to investigate the role of CB2 receptors in immune function.

Chemistry

PCPr is a synthetic compound that belongs to the class of phenylacetylindoles. It is structurally related to other synthetic cannabinoids such as JWH-018 and JWH-073.

Pharmacology

PCPr acts as a potent and selective agonist for the CB2 receptor. The CB2 receptor is primarily found in the peripheral nervous system, especially in immune cells, where it plays a role in immunomodulation and inflammation. Activation of this receptor by PCPr can lead to analgesic effects in animal studies.

Medical Use

While PCPr itself is not used medically, its ability to selectively activate CB2 receptors has made it a valuable tool in research investigating the therapeutic potential of these receptors. Studies using PCPr have suggested that CB2 receptor agonists could potentially be used in the treatment of pain, especially "atypical" pain that is not responsive to other treatments, as well as in the treatment of certain immune disorders.