IFITM3

IFITM3 is a gene in humans that encodes the Interferon Induced Transmembrane Protein 3. This protein is a crucial part of the immune response to viral infections, particularly influenza.

Function

The IFITM3 protein is part of the IFITM family of proteins, which are induced by type I and type II interferons. These proteins are known to play a significant role in inhibiting the proliferation of viruses in host cells. The IFITM3 protein, in particular, has been shown to inhibit the entry of viruses into cells, thereby preventing their replication and spread.

Clinical significance

Mutations in the IFITM3 gene have been associated with increased susceptibility to severe influenza infection. A specific variant of the gene, rs12252-C, has been linked to severe influenza in multiple studies. This variant results in a truncated form of the IFITM3 protein, which is less effective at inhibiting viral entry into cells.

Research

Research into the IFITM3 gene and its protein product has potential implications for the treatment of viral infections. Understanding the mechanisms by which the IFITM3 protein inhibits viral entry into cells could lead to the development of new antiviral therapies.

See also

• Interferon
• Influenza
• Viral infection

References

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