Cilazapril: Difference between revisions

Latest revision as of 11:04, 15 February 2025

Cilazapril[edit]

Cilazapril is a medication belonging to the class of drugs known as angiotensin-converting enzyme inhibitors (ACE inhibitors). It is primarily used in the treatment of hypertension (high blood pressure) and congestive heart failure. Cilazapril works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby leading to vasodilation and a reduction in blood pressure.

Mechanism of Action[edit]

Cilazapril inhibits the angiotensin-converting enzyme, which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a peptide that causes blood vessels to constrict, leading to increased blood pressure. By blocking this conversion, cilazapril causes blood vessels to relax and dilate, resulting in lower blood pressure and decreased workload on the heart.

Pharmacokinetics[edit]

Cilazapril is administered orally and is absorbed from the gastrointestinal tract. It is a prodrug, which means it is converted into its active form, cilazaprilat, in the liver. Cilazaprilat is the active metabolite that exerts the therapeutic effects. The drug is excreted primarily through the kidneys.

Clinical Uses[edit]

Cilazapril is used in the management of:

Hypertension: To lower high blood pressure and reduce the risk of cardiovascular disease.
Congestive heart failure: To improve symptoms and reduce mortality in patients with heart failure.

Side Effects[edit]

Common side effects of cilazapril include:

Less common but serious side effects may include:

Contraindications[edit]

Cilazapril is contraindicated in patients with:

History of angioedema related to previous ACE inhibitor therapy
Pregnancy
Severe renal artery stenosis

Related Pages[edit]

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-'''Cilazapril''' is an [[Angiotensin-converting enzyme inhibitors|angiotensin-converting enzyme inhibitor]] (ACE inhibitor) that is used for the treatment of [[hypertension]] and [[congestive heart failure]]. It was patented in 1980 and came into medical use in 1988. Cilazapril is available in countries such as Switzerland, Italy, and New Zealand.
+== Cilazapril ==
-==Etymology==
+[[File:Cilazapril_structure.svg|thumb|right|Chemical structure of Cilazapril]]
-The name "Cilazapril" is derived from the systematic (IUPAC) name which is (2S,4S)-1-[[2-(1H-indol-3-yl)propanoyl]pyrrolidine-2-carboxylic acid, 1-ethyl ester. The "Cila" part of the name is taken from the first four letters of the company that first synthesized it, Cilag. The "pril" ending is a common ending for ACE inhibitors.
-==Medical Uses==
+'''Cilazapril''' is a medication belonging to the class of drugs known as [[angiotensin-converting enzyme inhibitors]] (ACE inhibitors). It is primarily used in the treatment of [[hypertension]] (high blood pressure) and [[congestive heart failure]]. Cilazapril works by inhibiting the conversion of [[angiotensin I]] to [[angiotensin II]], a potent vasoconstrictor, thereby leading to vasodilation and a reduction in blood pressure.
-Cilazapril is used for the treatment of [[hypertension]] and [[congestive heart failure]]. It works by inhibiting the [[Angiotensin-converting enzyme|angiotensin-converting enzyme]] which is involved in the regulation of blood pressure.
-==Side Effects==
+== Mechanism of Action ==
-Common side effects of Cilazapril include dizziness, headache, fatigue, and cough. Serious side effects may include [[angioedema]], kidney problems, and high blood potassium.
+Cilazapril inhibits the [[angiotensin-converting enzyme]], which is responsible for the conversion of angiotensin I to angiotensin II. Angiotensin II is a peptide that causes blood vessels to constrict, leading to increased blood pressure. By blocking this conversion, cilazapril causes blood vessels to relax and dilate, resulting in lower blood pressure and decreased workload on the heart.
-==Related Terms==
+== Pharmacokinetics ==
-* [[Angiotensin-converting enzyme inhibitors|ACE inhibitors]]
+Cilazapril is administered orally and is absorbed from the gastrointestinal tract. It is a prodrug, which means it is converted into its active form, cilazaprilat, in the liver. Cilazaprilat is the active metabolite that exerts the therapeutic effects. The drug is excreted primarily through the kidneys.
+== Clinical Uses ==
+Cilazapril is used in the management of:
+* [[Hypertension]]: To lower high blood pressure and reduce the risk of [[cardiovascular disease]].
+* [[Congestive heart failure]]: To improve symptoms and reduce mortality in patients with heart failure.
+== Side Effects ==
+Common side effects of cilazapril include:
+* [[Cough]]
+* [[Dizziness]]
+* [[Fatigue]]
+* [[Headache]]
+Less common but serious side effects may include:
+* [[Angioedema]]
+* [[Hyperkalemia]]
+* [[Renal impairment]]
+== Contraindications ==
+Cilazapril is contraindicated in patients with:
+* History of [[angioedema]] related to previous ACE inhibitor therapy
+* [[Pregnancy]]
+* Severe [[renal artery stenosis]]
+== Related Pages ==
+* [[Angiotensin-converting enzyme inhibitor]]
 * [[Hypertension]]
 * [[Congestive heart failure]]
-==See Also==
-* [[List of ACE inhibitors]]
-* [[Angiotensin II receptor antagonist]]
 [[Category:ACE inhibitors]]
-[[Category:Prodrugs]]
+[[Category:Antihypertensive agents]]
-{{stub}}