Psychotic depression: Difference between revisions

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[[File:CT and MRI scan of the brain with melioidosis.jpg|thumb|right|Brain scan highlighting areas affected by depression.]]
{{SI}}
 
{{Infobox medical condition
| name            = Psychotic depression
| image          = [[File:Grieving_shadow.jpg|250px]]
| caption        = A depiction of the emotional turmoil associated with psychotic depression
| field          = [[Psychiatry]]
| symptoms        = [[Depression (mood)]], [[hallucinations]], [[delusions]]
| complications  = [[Suicide]], [[self-harm]]
| onset          = Typically in [[adulthood]]
| duration        = Can be [[chronic (medicine)|chronic]] or [[episodic]]
| types          = [[Major depressive disorder]] with psychotic features
| causes          = [[Genetic predisposition]], [[stressful life events]], [[neurobiological factors]]
| risks          = [[Family history of mental illness]], [[substance abuse]], [[chronic stress]]
| diagnosis      = [[Clinical assessment]], [[psychiatric evaluation]]
| differential    = [[Bipolar disorder]], [[schizophrenia]], [[schizoaffective disorder]]
| prevention      = Early intervention, [[psychotherapy]], [[medication]]
| treatment      = [[Antidepressants]], [[antipsychotics]], [[electroconvulsive therapy]]
| medication      = [[Selective serotonin reuptake inhibitors]], [[atypical antipsychotics]]
| prognosis      = Variable; can improve with treatment
| frequency      = Affects a small percentage of those with [[major depressive disorder]]
}}
[[File:CT and MRI scan of the brain with melioidosis.jpg|left|thumb|Brain scan highlighting areas affected by depression.]]
== Psychotic Depression ==
== Psychotic Depression ==
'''Psychotic depression''', also known as '''major depressive disorder with psychotic features''', is a subtype of [[major depressive disorder (MDD)]]. It is characterized by the presence of severe depressive symptoms accompanied by psychotic symptoms such as hallucinations, delusions, or both.
'''Psychotic depression''', also known as '''major depressive disorder with psychotic features''', is a subtype of [[major depressive disorder (MDD)]]. It is characterized by the presence of severe depressive symptoms accompanied by psychotic symptoms such as hallucinations, delusions, or both.
 
== Introduction ==
== Overview ==
Psychotic depression represents a severe form of depression. While patients experience typical depressive symptoms, they also exhibit signs of psychosis, making it distinct from other depressive disorders. It's crucial to recognize and treat this disorder promptly due to its increased risk of morbidity and suicidality.
Psychotic depression represents a severe form of depression. While patients experience typical depressive symptoms, they also exhibit signs of psychosis, making it distinct from other depressive disorders. It's crucial to recognize and treat this disorder promptly due to its increased risk of morbidity and suicidality.
== Symptoms ==
== Symptoms ==
=== Depressive Symptoms ===
=== Depressive Symptoms ===
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* Difficulty concentrating or indecisiveness
* Difficulty concentrating or indecisiveness
* Suicidal thoughts or actions
* Suicidal thoughts or actions
=== Psychotic Symptoms ===
=== Psychotic Symptoms ===
* '''Hallucinations:''' Sensing things that aren't there, such as hearing voices.
* '''Hallucinations:''' Sensing things that aren't there, such as hearing voices.
* '''Delusions:''' Strongly held false beliefs. In psychotic depression, these often relate to themes of guilt, punishment, or worthlessness.
* '''Delusions:''' Strongly held false beliefs. In psychotic depression, these often relate to themes of guilt, punishment, or worthlessness.
 
[[File:Depression-loss of loved one.jpg|left|thumb|Individual displaying signs of severe depression.]]
[[File:Depression-loss of loved one.jpg|thumb|left|Individual displaying signs of severe depression.]]
 
== Causes and Risk Factors ==
== Causes and Risk Factors ==
While the exact cause is unknown, several factors can contribute:
While the exact cause is unknown, several factors can contribute:
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* Major life changes or traumatic events
* Major life changes or traumatic events
* Certain medical conditions or medications
* Certain medical conditions or medications
== Diagnosis ==
== Diagnosis ==
Diagnosis requires a comprehensive clinical evaluation by a mental health professional. This involves:
Diagnosis requires a comprehensive clinical evaluation by a mental health professional. This involves:
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* Assessment of both depressive and psychotic symptoms
* Assessment of both depressive and psychotic symptoms
* Rule out other medical conditions or substances causing the symptoms
* Rule out other medical conditions or substances causing the symptoms
== Treatment ==
== Treatment ==
Treatment for psychotic depression often involves a combination of:
Treatment for psychotic depression often involves a combination of:
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* '''[[Electroconvulsive therapy (ECT)]]:''' In severe cases or when medication isn't effective.
* '''[[Electroconvulsive therapy (ECT)]]:''' In severe cases or when medication isn't effective.
* '''Psychotherapy:''' Especially cognitive-behavioral therapy, can be beneficial in conjunction with medication.
* '''Psychotherapy:''' Especially cognitive-behavioral therapy, can be beneficial in conjunction with medication.
 
[[File:Psychotherapy.JPG|left|thumb|Psychotherapy can be beneficial for individuals with psychotic depression.]]
[[File:Psychotherapy.JPG|thumb|right|Psychotherapy can be beneficial for individuals with psychotic depression.]]
 
== Prognosis ==
== Prognosis ==
With prompt and appropriate treatment, many individuals with psychotic depression can experience a full recovery. However, without treatment, the condition can be life-threatening due to the high risk of suicide.
With prompt and appropriate treatment, many individuals with psychotic depression can experience a full recovery. However, without treatment, the condition can be life-threatening due to the high risk of suicide.
== Prevention ==
== Prevention ==
While it's challenging to prevent psychotic depression, early intervention, regular medical check-ups, and seeking help when initial symptoms emerge can be beneficial.
While it's challenging to prevent psychotic depression, early intervention, regular medical check-ups, and seeking help when initial symptoms emerge can be beneficial.
== See Also ==
== See Also ==
* [[Major depressive disorder]]
* [[Major depressive disorder]]
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* [[Hallucinations]]
* [[Hallucinations]]
* [[Delusions]]
* [[Delusions]]
== External Links ==
== External Links ==
* [https://www.nimh.nih.gov/ National Institute of Mental Health (NIMH)]
* [https://www.nimh.nih.gov/ National Institute of Mental Health (NIMH)]
* [https://www.dbsalliance.org/ Depression and Bipolar Support Alliance]
* [https://www.dbsalliance.org/ Depression and Bipolar Support Alliance]
[[Category:Mental health]]
[[Category:Mental health]]
[[Category:Psychotic disorders]]
[[Category:Psychotic disorders]]
[[Category:Depressive disorders]]
[[Category:Depressive disorders]]
{{stub}}
{{stub}}

Latest revision as of 21:09, 8 April 2025

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Psychotic depression
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Depression (mood), hallucinations, delusions
Complications Suicide, self-harm
Onset Typically in adulthood
Duration Can be chronic or episodic
Types Major depressive disorder with psychotic features
Causes Genetic predisposition, stressful life events, neurobiological factors
Risks Family history of mental illness, substance abuse, chronic stress
Diagnosis Clinical assessment, psychiatric evaluation
Differential diagnosis Bipolar disorder, schizophrenia, schizoaffective disorder
Prevention Early intervention, psychotherapy, medication
Treatment Antidepressants, antipsychotics, electroconvulsive therapy
Medication Selective serotonin reuptake inhibitors, atypical antipsychotics
Prognosis Variable; can improve with treatment
Frequency Affects a small percentage of those with major depressive disorder
Deaths N/A


Brain scan highlighting areas affected by depression.

Psychotic Depression[edit]

Psychotic depression, also known as major depressive disorder with psychotic features, is a subtype of major depressive disorder (MDD). It is characterized by the presence of severe depressive symptoms accompanied by psychotic symptoms such as hallucinations, delusions, or both.

Introduction[edit]

Psychotic depression represents a severe form of depression. While patients experience typical depressive symptoms, they also exhibit signs of psychosis, making it distinct from other depressive disorders. It's crucial to recognize and treat this disorder promptly due to its increased risk of morbidity and suicidality.

Symptoms[edit]

Depressive Symptoms[edit]

  • Persistent feelings of sadness or hopelessness
  • Loss of interest in previously enjoyed activities
  • Significant weight changes or appetite disturbances
  • Insomnia or hypersomnia
  • Fatigue or loss of energy
  • Feelings of worthlessness or guilt
  • Difficulty concentrating or indecisiveness
  • Suicidal thoughts or actions

Psychotic Symptoms[edit]

  • Hallucinations: Sensing things that aren't there, such as hearing voices.
  • Delusions: Strongly held false beliefs. In psychotic depression, these often relate to themes of guilt, punishment, or worthlessness.
Individual displaying signs of severe depression.

Causes and Risk Factors[edit]

While the exact cause is unknown, several factors can contribute:

  • Biological differences, including changes in brain chemistry and structure
  • Family history of depressive or psychotic disorders
  • Prolonged or chronic stress
  • Major life changes or traumatic events
  • Certain medical conditions or medications

Diagnosis[edit]

Diagnosis requires a comprehensive clinical evaluation by a mental health professional. This involves:

  • Detailed psychiatric history
  • Assessment of both depressive and psychotic symptoms
  • Rule out other medical conditions or substances causing the symptoms

Treatment[edit]

Treatment for psychotic depression often involves a combination of:

  • Antidepressant Medications: To address depressive symptoms.
  • Antipsychotic Medications: To treat hallucinations or delusions.
  • Electroconvulsive therapy (ECT): In severe cases or when medication isn't effective.
  • Psychotherapy: Especially cognitive-behavioral therapy, can be beneficial in conjunction with medication.
Psychotherapy can be beneficial for individuals with psychotic depression.

Prognosis[edit]

With prompt and appropriate treatment, many individuals with psychotic depression can experience a full recovery. However, without treatment, the condition can be life-threatening due to the high risk of suicide.

Prevention[edit]

While it's challenging to prevent psychotic depression, early intervention, regular medical check-ups, and seeking help when initial symptoms emerge can be beneficial.

See Also[edit]

External Links[edit]

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