* Trifarotene ('''AKLIEF''') Cream is a [[retinoid]] used for the [[topical]] treatment of [[acne vulgaris]].
[[File:Trifarotene.svg|thumb|Chemical structure of Trifarotene]]
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'''Trifarotene''' is a [[retinoid]] medication primarily used for the treatment of [[acne vulgaris]]. It is notable for being a selective retinoic acid receptor (RAR) gamma agonist, which is believed to contribute to its efficacy and safety profile.
Trifarotene is indicated for the topical treatment of acne vulgaris in patients aged 9 years and older. It is applied once daily to the affected areas. The medication works by modulating the differentiation and proliferation of epithelial cells, which helps to reduce the formation of acne lesions.
* AKLIEF Cream is a [[retinoid]] indicated for the [[topical]] treatment of [[acne vulgaris]] in patients 9 years of age and older.
== Mechanism of Action ==
Trifarotene selectively targets the RAR gamma subtype, which is the most prevalent retinoic acid receptor in the skin. This selectivity is thought to minimize systemic exposure and reduce the risk of side effects commonly associated with other retinoids. By binding to RAR gamma, trifarotene influences gene expression, leading to decreased inflammation and normalization of follicular epithelial desquamation.
== '''How does this medicine work?''' ==
== Side Effects ==
Common side effects of trifarotene include skin irritation, dryness, and erythema at the site of application. These effects are generally mild to moderate in severity and tend to decrease with continued use. Patients are advised to use moisturizers and avoid excessive sun exposure while using trifarotene.
* Trifarotene is an '''[[agonist]] of retinoic acid receptors (RAR), with particular activity at the gamma subtype of RAR'''.
== History ==
* Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation.
Trifarotene was developed by [[Galderma]] and received approval from the [[United States Food and Drug Administration]] (FDA) in October 2019. It represents a novel advancement in the treatment of acne due to its receptor selectivity.
* The exact process by which trifarotene ameliorates acne is unknown.
== '''Who Should Not Use this medicine ?''' ==
== Related Pages ==
* [[Acne vulgaris]]
* [[Retinoid]]
* [[Retinoic acid receptor]]
* This medicine have no usage limitations.
== References ==
* [https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-acne-vulgaris FDA Approves New Treatment for Acne Vulgaris]
== '''What drug interactions can this medicine cause?''' ==
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234567/ Trifarotene: A New Topical Retinoid for Acne Vulgaris]
* AKLIEF Cream is not expected to affect the circulating concentrations of oral hormonal [[contraceptives]] containing [[ethinyl estradiol]] and [[levonorgestrel]].
== '''Is this medicine FDA approved?''' ==
* It was approved for use in the United States in 2019.
== '''How should this medicine be used?''' ==
'''Administration'''
* Apply a thin layer of AKLIEF Cream to the affected areas once daily, in the evening, on clean and dry skin.
* One pump actuation should be enough to cover the face (i.e., forehead, cheeks, nose, and chin).
* Two actuations of the pump should be enough to cover the upper trunk (i.e., reachable upper back, shoulders and chest). One additional pump actuation may be used for middle and lower back if acne is present.
* The use of a moisturizer is recommended as frequently as needed from the initiation of treatment.
* Avoid contact with the eyes, lips, paranasal creases, mucous membranes.
* AKLIEF Cream is for topical use only. Not for oral, ophthalmic, or intravaginal use.
== '''What are the dosage forms and brand names of this medicine?''' ==
This medicine is available in fallowing doasage form:
* '''As Cream:''' 0.005% trifarotene
This medicine is available in fallowing brand namesː
*'''AKLIEF'''
=='''What side effects can this medication cause?'''==
The most common side effects of this medicine include:
* site irritation
* application site [[pruritus]]
* sunburn
==''' What special precautions should I follow?''' =
* Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning.
* Use a moisturizer from the initiation of treatment, and, if appropriate, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use.
* Avoid application of AKLIEF Cream to cuts, abrasions, or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream.
* Minimize unprotected exposure to ultraviolet rays (including sunlight and sunlamps) during treatment with AKLIEF Cream. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.
== '''What to do in case of emergency/overdose?''' ==
* {{overdose}}
== '''Can this medicine be used in pregnancy?''' ==
* Available data from clinical trials with AKLIEF Cream use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.
=='''Can this medicine be used in children?'''==
* Safety and effectiveness of AKLIEF Cream for the topical treatment of acne vulgaris have been established in pediatric patients age 9 years to 17 years.
* Safety and effectiveness of AKLIEF Cream have not been established in pediatric subjects under the age of 9 years.
== '''What are the active and inactive ingredients in this medicine?''' ==
'''Active ingredient: '''
* Trifarotene
'''Inactive ingredients:'''
* Allantoin
* Acrylic Acid/Sodium Acrylate Copolymer
* Isohexadecane
* Cyclomethicone 5
* Alcohol
* Medium-Chain Triglycerides
* Phenoxyethanol
* Propylene Glycol
* Water
== '''Who manufactures and distributes this medicine?''' ==
* Packager: Galderma Laboratories, L.P.
== '''What should I know about storage and disposal of this medication?''' ==
* Store at 20 to 25˚C (68 to 77˚F) with excursions permitted to 15°to 30°C (59° to 86°F).
Trifarotene is a retinoid medication primarily used for the treatment of acne vulgaris. It is notable for being a selective retinoic acid receptor (RAR) gamma agonist, which is believed to contribute to its efficacy and safety profile.
Medical Uses
Trifarotene is indicated for the topical treatment of acne vulgaris in patients aged 9 years and older. It is applied once daily to the affected areas. The medication works by modulating the differentiation and proliferation of epithelial cells, which helps to reduce the formation of acne lesions.
Mechanism of Action
Trifarotene selectively targets the RAR gamma subtype, which is the most prevalent retinoic acid receptor in the skin. This selectivity is thought to minimize systemic exposure and reduce the risk of side effects commonly associated with other retinoids. By binding to RAR gamma, trifarotene influences gene expression, leading to decreased inflammation and normalization of follicular epithelial desquamation.
Side Effects
Common side effects of trifarotene include skin irritation, dryness, and erythema at the site of application. These effects are generally mild to moderate in severity and tend to decrease with continued use. Patients are advised to use moisturizers and avoid excessive sun exposure while using trifarotene.
History
Trifarotene was developed by Galderma and received approval from the United States Food and Drug Administration (FDA) in October 2019. It represents a novel advancement in the treatment of acne due to its receptor selectivity.
