AllTrials: Difference between revisions

Latest revision as of 17:18, 5 March 2025

AllTrials[edit]

AllTrials logo

AllTrials is an international campaign advocating for the registration and reporting of all clinical trials. The initiative seeks to ensure that all past and present clinical trials are registered and their full methods and summary results are reported. This transparency is crucial for the advancement of medical knowledge and the improvement of patient care.

Background[edit]

The AllTrials campaign was launched in January 2013 by a coalition of organizations and individuals, including Sense about Science, Bad Science, the British Medical Journal, the Centre for Evidence-Based Medicine, and the James Lind Initiative. The campaign was initiated in response to growing concerns about the lack of transparency in clinical trial reporting, which can lead to biased medical literature and misinformed healthcare decisions.

Objectives[edit]

The primary objectives of the AllTrials campaign are:

To ensure that all clinical trials, past and present, are registered with a publicly accessible database.
To ensure that the full methods and summary results of all trials are reported.
To advocate for the implementation of policies and regulations that mandate the registration and reporting of clinical trials.

Importance of Clinical Trial Transparency[edit]

Clinical trials are essential for determining the safety and efficacy of new medical treatments. However, when trials are not registered or their results are not reported, it can lead to a skewed understanding of a treatment's effectiveness. This lack of transparency can result in:

Publication bias, where only positive results are published, giving a false impression of a treatment's efficacy.
Research waste, as future studies may unknowingly repeat past trials.
Harm to patients, who may receive ineffective or harmful treatments based on incomplete data.

Campaign Activities[edit]

The AllTrials campaign engages in various activities to promote its objectives, including:

Lobbying policymakers and regulatory bodies to enforce trial registration and reporting.
Raising public awareness about the importance of clinical trial transparency.
Collaborating with researchers, healthcare professionals, and patient advocacy groups to support the campaign's goals.

Support and Endorsements[edit]

The AllTrials campaign has received widespread support from numerous organizations and individuals worldwide. Notable supporters include:

World Health Organization
Cochrane Collaboration
National Institute for Health and Care Excellence (NICE)
Various academic institutions and research organizations

Challenges and Criticisms[edit]

Despite its widespread support, the AllTrials campaign faces several challenges, including:

Resistance from some pharmaceutical companies and researchers who are concerned about the potential impact on intellectual property and competitive advantage.
The logistical and financial challenges of registering and reporting all past trials.
Ensuring compliance with new regulations and policies.

Related Pages[edit]

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-{{Use dmy dates|date=October 2023}}
+== AllTrials ==
-{{No footnotes|date=October 2023}}
 [[File:AllTrials-logo.png|AllTrials logo|thumb|right]]
-'''AllTrials''' is an international campaign advocating for the registration and reporting of all clinical trials. The initiative seeks to ensure that all past and present clinical trials are registered and their full methods and summary results are reported. This is to address the issue of publication bias and selective reporting, which can lead to an incomplete and potentially misleading understanding of the efficacy and safety of medical interventions.
+'''AllTrials''' is an international campaign advocating for the registration and reporting of all clinical trials. The initiative seeks to ensure that all past and present clinical trials are registered and their full methods and summary results are reported. This transparency is crucial for the advancement of medical knowledge and the improvement of patient care.
-==Background==
+== Background ==
-The AllTrials campaign was launched in January 2013 by a coalition of organizations and individuals, including [[Sense about Science]], [[Bad Science]], the [[British Medical Journal]], the [[James Lind Initiative]], and the [[Centre for Evidence-Based Medicine]]. The campaign was initiated in response to growing concerns about the lack of transparency in clinical trial reporting, which can have serious implications for patient safety and the integrity of medical research.
+The AllTrials campaign was launched in January 2013 by a coalition of organizations and individuals, including [[Sense about Science]], [[Bad Science]], the [[British Medical Journal]], the [[Centre for Evidence-Based Medicine]], and the [[James Lind Initiative]]. The campaign was initiated in response to growing concerns about the lack of transparency in clinical trial reporting, which can lead to biased medical literature and misinformed healthcare decisions.
-==Objectives==
+== Objectives ==
 The primary objectives of the AllTrials campaign are:
-* To ensure that all clinical trials, past and present, are registered on a publicly accessible database.
+* To ensure that all clinical trials, past and present, are registered with a publicly accessible database.
 * To ensure that the full methods and summary results of all trials are reported.
-* To promote transparency and accountability in clinical research.
+* To advocate for the implementation of policies and regulations that mandate the registration and reporting of clinical trials.
+== Importance of Clinical Trial Transparency ==
+Clinical trials are essential for determining the safety and efficacy of new medical treatments. However, when trials are not registered or their results are not reported, it can lead to a skewed understanding of a treatment's effectiveness. This lack of transparency can result in:
+* [[Publication bias]], where only positive results are published, giving a false impression of a treatment's efficacy.
+* [[Research waste]], as future studies may unknowingly repeat past trials.
+* [[Harm to patients]], who may receive ineffective or harmful treatments based on incomplete data.
-==Rationale==
+== Campaign Activities ==
-The rationale behind the AllTrials campaign is based on the recognition that incomplete reporting of clinical trials can lead to biased evidence, which in turn can affect clinical decision-making and policy. When only positive results are published, while negative or inconclusive results are withheld, it creates a skewed understanding of a treatment's effectiveness. This can result in the use of ineffective or harmful treatments and the misallocation of healthcare resources.
+The AllTrials campaign engages in various activities to promote its objectives, including:
-==Support and Endorsements==
+* Lobbying policymakers and regulatory bodies to enforce trial registration and reporting.
-The AllTrials campaign has received widespread support from various stakeholders in the medical and scientific communities. This includes endorsements from major research funders, academic institutions, patient groups, and professional societies. The campaign has also garnered support from prominent figures in the field of medicine and science, who have advocated for greater transparency in clinical research.
+* Raising public awareness about the importance of clinical trial transparency.
+* Collaborating with researchers, healthcare professionals, and patient advocacy groups to support the campaign's goals.
-==Impact==
+== Support and Endorsements ==
-Since its inception, the AllTrials campaign has had a significant impact on the discourse surrounding clinical trial transparency. It has raised awareness about the importance of registering and reporting all clinical trials and has influenced policy changes in several countries. Some regulatory agencies have introduced measures to improve the transparency of clinical trial data, and there has been an increase in the number of trials being registered and reported.
+The AllTrials campaign has received widespread support from numerous organizations and individuals worldwide. Notable supporters include:
-==Challenges==
+* [[World Health Organization]]
-Despite its successes, the AllTrials campaign faces several challenges. These include resistance from some pharmaceutical companies and researchers who are reluctant to disclose negative or inconclusive results. Additionally, there are logistical and technical challenges associated with registering and reporting all clinical trials, particularly those conducted in the past.
+* [[Cochrane Collaboration]]
+* [[National Institute for Health and Care Excellence]] (NICE)
+* Various academic institutions and research organizations
-==Future Directions==
+== Challenges and Criticisms ==
-The AllTrials campaign continues to advocate for greater transparency in clinical research. Future directions include:
+Despite its widespread support, the AllTrials campaign faces several challenges, including:
-* Expanding the campaign's reach to include more countries and regions.
+* Resistance from some pharmaceutical companies and researchers who are concerned about the potential impact on intellectual property and competitive advantage.
-* Collaborating with regulatory agencies to develop and implement policies that mandate the registration and reporting of all clinical trials.
+* The logistical and financial challenges of registering and reporting all past trials.
-* Engaging with the public and patient groups to raise awareness about the importance of clinical trial transparency.
+* Ensuring compliance with new regulations and policies.
-==Related pages==
+== Related Pages ==
 * [[Clinical trial]]
 * [[Publication bias]]
 * [[Evidence-based medicine]]
-* [[Sense about Science]]
+* [[Research ethics]]
-[[Category:Clinical research]]
+[[Category:Clinical trials]]
-[[Category:Medical ethics]]
+[[Category:Medical research]]
 [[Category:Transparency (behavior)]]