Pirisudanol: Difference between revisions

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{{Short description|A nootropic drug used for cognitive enhancement}}
'''Pirisudanol''' ('''Mentis''', '''Menthen''', '''Mentium''', '''Nadex''', '''Nadexen''', '''Nadexon''', '''Pridana''', '''Stivane'''), also known as '''pyrisuccideanol''', is the [[succinic acid]] [[ester]] of [[pyridoxine]] (a form of [[vitamin B6|vitamin B<sub>6</sub>]]) and of [[deanol]] (DMAE).<ref name="urlPsycho-Babble Medication Thread 69493">{{cite web | url = +http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20010708/msgs/69493.html#69493 | title = Psycho-Babble Medication Thread 69493 | format = | work = | accessdate = }}</ref> It has been used in [[Europe]] in the treatment of mild [[cognitive impairment]] as well as [[Fatigue (medical)|fatigue]] and [[major depression|depression]].<ref name="urlPsycho-Babble Medication Thread 69493">{{cite web | url = +http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20010708/msgs/69493.html#69493 | title = Psycho-Babble Medication Thread 69493 | format = | work = | accessdate = }}</ref><ref name="isbn0-412-46630-9">{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | pages = | isbn = 0-412-46630-9 | oclc = | doi = | url = http://books.google.com/books?id=A0THacd46ZsC&lpg=PA1626&dq=Pirisudanol&as_brr=3&pg=PA1626#v=onepage&q=&f=false}}</ref><ref name="pmid1261486">{{cite journal | author = Bathien N, Willer JC, Hugelin A | title = [Effect of psychotropic drugs on physiological variations and psychometric scores during attention] | language = French | journal = L'Encéphale | volume = 2 | issue = 1 | pages = 55–60 | year = 1976 | pmid = 1261486 | doi = | url = }}</ref><ref name="pmid7297757">{{cite journal | author = Murphy JE | title = An evaluation of pyrisuccideanol maleate (Nadex) in the treatment of mild to moderate depression in patients aged 55 years and over, presenting in general practice | journal = The Journal of International Medical Research | volume = 9 | issue = 5 | pages = 330–7 | year = 1981 | pmid = 7297757 | doi = | url = }}</ref><ref name="pmid6138876">{{cite journal | author = Zmorski T | title = [Experience with Nadex in an ambulatory psychiatric practice] | language = German | journal = Therapeutische Umschau. Revue Thérapeutique | volume = 40 | issue = 9 | pages = 817–20 |date=September 1983 | pmid = 6138876 | doi = | url = }}</ref>


== See also ==
'''Pirisudanol''' is a [[nootropic]] drug that has been used for its potential cognitive-enhancing effects. It is a compound that combines two molecules of [[pyridoxine]] (vitamin B6) with a molecule of [[deanol]], also known as dimethylaminoethanol (DMAE). This combination is believed to enhance cognitive function, improve mood, and increase mental alertness.
* [[Pyritinol]]
 
==Pharmacology==
Pirisudanol is thought to work by increasing the levels of certain neurotransmitters in the brain, particularly [[acetylcholine]]. Acetylcholine is a neurotransmitter associated with memory and learning. By enhancing acetylcholine levels, pirisudanol may improve cognitive functions such as memory, attention, and mental clarity.
 
The drug is also believed to have antioxidant properties, which may protect brain cells from oxidative stress and damage. This neuroprotective effect could contribute to its potential benefits in cognitive enhancement.
 
==Uses==
Pirisudanol has been used in various contexts for its purported cognitive benefits. It is often marketed as a dietary supplement for improving memory, focus, and overall mental performance. Some users report enhanced mood and reduced symptoms of mental fatigue when taking pirisudanol.
 
In some countries, pirisudanol has been used in the treatment of cognitive decline associated with aging or neurodegenerative conditions. However, its efficacy and safety for these uses are not well-established, and it is not approved for medical use in all regions.
 
==Side Effects==
As with many nootropic substances, pirisudanol may cause side effects in some individuals. Common side effects include headaches, insomnia, and gastrointestinal disturbances. These effects are generally mild and transient.
 
More serious side effects are rare but can occur, particularly with high doses or prolonged use. It is important for users to adhere to recommended dosages and consult with a healthcare professional before starting any new supplement regimen.
 
==Legal Status==
The legal status of pirisudanol varies by country. In some regions, it is available as an over-the-counter supplement, while in others, it may be regulated as a prescription medication. Users should check the regulations in their specific location before purchasing or using pirisudanol.
 
==Related pages==
* [[Nootropic]]
* [[Acetylcholine]]
* [[Pyridoxine]]
* [[Deanol]]


== References ==
{{Reflist|2}}
{{Nootropics}}
{{Antidepressants}}
{{Cholinergics}}
[[Category:Pyridines]]
[[Category:Phenols]]
[[Category:Alcohols]]
[[Category:Succinates]]
[[Category:Prodrugs]]
[[Category:Nootropics]]
[[Category:Nootropics]]
[[Category:Antidepressants]]
[[Category:Vitamins]]
{{nervous-system-drug-stub}}
[[Category:Neurotransmitters]]
{{nt}}
<gallery>
File:Pirisudanol.png|Pirisudanol
File:Pirisudanol synthesis.svg|Pirisudanol synthesis
</gallery>

Latest revision as of 19:05, 22 March 2025

A nootropic drug used for cognitive enhancement


Pirisudanol is a nootropic drug that has been used for its potential cognitive-enhancing effects. It is a compound that combines two molecules of pyridoxine (vitamin B6) with a molecule of deanol, also known as dimethylaminoethanol (DMAE). This combination is believed to enhance cognitive function, improve mood, and increase mental alertness.

Pharmacology[edit]

Pirisudanol is thought to work by increasing the levels of certain neurotransmitters in the brain, particularly acetylcholine. Acetylcholine is a neurotransmitter associated with memory and learning. By enhancing acetylcholine levels, pirisudanol may improve cognitive functions such as memory, attention, and mental clarity.

The drug is also believed to have antioxidant properties, which may protect brain cells from oxidative stress and damage. This neuroprotective effect could contribute to its potential benefits in cognitive enhancement.

Uses[edit]

Pirisudanol has been used in various contexts for its purported cognitive benefits. It is often marketed as a dietary supplement for improving memory, focus, and overall mental performance. Some users report enhanced mood and reduced symptoms of mental fatigue when taking pirisudanol.

In some countries, pirisudanol has been used in the treatment of cognitive decline associated with aging or neurodegenerative conditions. However, its efficacy and safety for these uses are not well-established, and it is not approved for medical use in all regions.

Side Effects[edit]

As with many nootropic substances, pirisudanol may cause side effects in some individuals. Common side effects include headaches, insomnia, and gastrointestinal disturbances. These effects are generally mild and transient.

More serious side effects are rare but can occur, particularly with high doses or prolonged use. It is important for users to adhere to recommended dosages and consult with a healthcare professional before starting any new supplement regimen.

Legal Status[edit]

The legal status of pirisudanol varies by country. In some regions, it is available as an over-the-counter supplement, while in others, it may be regulated as a prescription medication. Users should check the regulations in their specific location before purchasing or using pirisudanol.

Related pages[edit]