CDV3 (gene): Difference between revisions

From WikiMD's Wellness Encyclopedia

CSV import
Tags: mobile edit mobile web edit
CSV import
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
'''CDV3''' is a [[gene]] that in humans is encoded by the CDV3 homolog (CDV3) gene. The CDV3 gene is located on [[chromosome 3]] (3q26.31) and spans approximately 16.5 kilobases. The gene is composed of 10 exons and encodes a protein of 243 amino acids.
== CDV3 (gene) ==
 
[[File:CDV3_Chromosome_Location.jpg|thumb|right|Chromosomal location of the CDV3 gene.]]
 
'''CDV3''' (Caspase recruitment domain family member 3) is a gene that encodes a protein involved in various cellular processes, including apoptosis and immune response. The CDV3 gene is located on chromosome 3 in humans.
 
== Structure ==
 
[[File:Predicted_secondary_structure_of_CDV3.png|thumb|left|Predicted secondary structure of the CDV3 protein.]]
 
The CDV3 gene consists of multiple exons and introns, which are transcribed and spliced to produce a mature mRNA. The protein encoded by CDV3 is predicted to have a specific secondary structure, as shown in the accompanying image. This structure is crucial for its function in cellular processes.
 
[[File:Predicted_CDV3_3D_Structure.png|thumb|right|Predicted 3D structure of the CDV3 protein.]]
 
The three-dimensional structure of the CDV3 protein has been predicted using computational models. This structure provides insights into the potential functional domains and interaction sites of the protein.
 
== Expression ==
 
[[File:CDV3_Human_HPA_RNA-seq_Normal_Tissue_Expression.png|thumb|left|RNA-seq data showing CDV3 expression in normal human tissues.]]
 
The expression of CDV3 varies across different tissues. RNA sequencing data indicates that CDV3 is expressed in several human tissues, with varying levels of expression. This differential expression suggests that CDV3 may have tissue-specific roles.
 
[[File:Tissue-specific_circular_RNA_induction_for_CDV3.png|thumb|right|Tissue-specific circular RNA induction for CDV3.]]
 
In addition to linear mRNA, CDV3 is also involved in the formation of circular RNAs, which are known to play roles in gene regulation and cellular stress responses.


== Function ==
== Function ==
The CDV3 gene is involved in the regulation of [[cell division]] and [[cell cycle]]. It is also associated with the [[cilia]] and [[flagella]] assembly. The protein encoded by this gene is a component of the [[dynein]] regulatory complex (DRC), which is a key regulator of ciliary and flagellar movement.


== Clinical significance ==
CDV3 is involved in the regulation of apoptosis and immune responses. It interacts with other proteins in the cell to modulate these processes. The protein's structure and expression patterns suggest it may have additional roles in cellular signaling pathways.
Mutations in the CDV3 gene have been associated with [[primary ciliary dyskinesia]] (PCD), a rare genetic disorder characterized by chronic respiratory tract infections, abnormally positioned internal organs, and the inability to have children.  
 
== Regulation ==
 
[[File:Predicted_Sites_of_CDV3_Protein_Regulation.png|thumb|left|Predicted sites of regulation on the CDV3 protein.]]
 
The activity of the CDV3 protein is regulated by various post-translational modifications. These modifications can alter the protein's function and interactions, thereby influencing cellular processes.
 
== Transcriptome ==
 
[[File:CDV3_RNA_sequencing_of_total_RNA_from_20_human_tissues.png|thumb|right|RNA sequencing of total RNA from 20 human tissues showing CDV3 expression.]]


== Research ==
Transcriptome analysis has revealed the presence of CDV3 transcripts in multiple human tissues. This data provides a comprehensive view of the gene's expression profile and potential functional roles.
Research on the CDV3 gene is ongoing, with studies focusing on its role in cell division and its association with primary ciliary dyskinesia. Understanding the function of the CDV3 gene may lead to new treatments for diseases associated with cell division abnormalities and ciliary dysfunction.


== See also ==
[[File:CDV3_Illumina_bodyMap2_transcriptome.png|thumb|left|Illumina BodyMap2 transcriptome data for CDV3.]]
* [[Gene]]
* [[Chromosome 3]]
* [[Cell division]]
* [[Cell cycle]]
* [[Cilia]]
* [[Flagella]]
* [[Dynein]]
* [[Primary ciliary dyskinesia]]


== References ==
The Illumina BodyMap2 project has further characterized the expression of CDV3, highlighting its presence in various tissues and its potential involvement in diverse biological processes.
<references />


[[Category:Genes]]
== Related pages ==
[[Category:Human proteins]]
* [[Apoptosis]]
[[Category:Cell biology]]
* [[Immune response]]
[[Category:Genetics]]
* [[Chromosome 3 (human)]]
[[Category:Medicine]]
* [[Gene expression]]


{{medicine-stub}}
[[Category:Human genes]]
<gallery>
[[Category:Apoptosis]]
File:CDV3_Chromosome_Location.jpg|Chromosome location of CDV3
[[Category:Immune system]]
File:Predicted_secondary_structure_of_CDV3.png|Predicted secondary structure of CDV3
File:Predicted_CDV3_3D_Structure.png|Predicted 3D structure of CDV3
File:CDV3_Human_HPA_RNA-seq_Normal_Tissue_Expression.png|Human HPA RNA-seq normal tissue expression of CDV3
File:Tissue-specific_circular_RNA_induction_for_CDV3.png|Tissue-specific circular RNA induction for CDV3
File:CDV3_RNA_sequencing_of_total_RNA_from_20_human_tissues.png|RNA sequencing of total RNA from 20 human tissues for CDV3
File:CDV3_Illumina_bodyMap2_transcriptome.png|Illumina bodyMap2 transcriptome for CDV3
File:Predicted_Sites_of_CDV3_Protein_Regulation.png|Predicted sites of CDV3 protein regulation
File:Phylogenetic_Tree_of_Species_with_CDV3_Orthologs.png|Phylogenetic tree of species with CDV3 orthologs
</gallery>

Latest revision as of 14:12, 21 February 2025

CDV3 (gene)[edit]

Chromosomal location of the CDV3 gene.

CDV3 (Caspase recruitment domain family member 3) is a gene that encodes a protein involved in various cellular processes, including apoptosis and immune response. The CDV3 gene is located on chromosome 3 in humans.

Structure[edit]

Predicted secondary structure of the CDV3 protein.

The CDV3 gene consists of multiple exons and introns, which are transcribed and spliced to produce a mature mRNA. The protein encoded by CDV3 is predicted to have a specific secondary structure, as shown in the accompanying image. This structure is crucial for its function in cellular processes.

Predicted 3D structure of the CDV3 protein.

The three-dimensional structure of the CDV3 protein has been predicted using computational models. This structure provides insights into the potential functional domains and interaction sites of the protein.

Expression[edit]

RNA-seq data showing CDV3 expression in normal human tissues.

The expression of CDV3 varies across different tissues. RNA sequencing data indicates that CDV3 is expressed in several human tissues, with varying levels of expression. This differential expression suggests that CDV3 may have tissue-specific roles.

Tissue-specific circular RNA induction for CDV3.

In addition to linear mRNA, CDV3 is also involved in the formation of circular RNAs, which are known to play roles in gene regulation and cellular stress responses.

Function[edit]

CDV3 is involved in the regulation of apoptosis and immune responses. It interacts with other proteins in the cell to modulate these processes. The protein's structure and expression patterns suggest it may have additional roles in cellular signaling pathways.

Regulation[edit]

Predicted sites of regulation on the CDV3 protein.

The activity of the CDV3 protein is regulated by various post-translational modifications. These modifications can alter the protein's function and interactions, thereby influencing cellular processes.

Transcriptome[edit]

RNA sequencing of total RNA from 20 human tissues showing CDV3 expression.

Transcriptome analysis has revealed the presence of CDV3 transcripts in multiple human tissues. This data provides a comprehensive view of the gene's expression profile and potential functional roles.

Illumina BodyMap2 transcriptome data for CDV3.

The Illumina BodyMap2 project has further characterized the expression of CDV3, highlighting its presence in various tissues and its potential involvement in diverse biological processes.

Related pages[edit]