5F-AMB: Difference between revisions

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{{Short description|Synthetic cannabinoid}}
{{DISPLAYTITLE:5F-AMB}}
{{Drugbox
| verifiedfields = changed
| verifiedrevid = 477002547
| IUPAC_name = (S)-Methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate
| image = 5F-AMB-PINACA.svg
| width = 200
| legal_status =
| routes_of_administration =
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
| CAS_number = 1800101-60-3
| PubChem = 86273332
| ChemSpiderID = 52085068
| UNII =
| KEGG =
| ChEMBL = 3301618
| C=19
| H=26
| F=1
| N=3
| O=3
| smiles = CC(C)[C@@H](C(=O)OC)NC(=O)c1nn(CCCCC(F)F)c2c1cccc2
| StdInChI = 1S/C19H26FN3O3/c1-13(2)16(19(25)26-3)22-18(24)17-15-10-7-6-9-14(15)12-23(21-17)11-8-4-5-11/h6-7,9-10,12-13,16H,4-5,8H2,1-3H3,(H,22,24)/t16-/m0/s1
| StdInChIKey =
}}


'''5F-AMB''' is a synthetic [[cannabinoid]] that has been used as a designer drug. It is a potent agonist of the [[CB1 receptor]] and [[CB2 receptor]], which are part of the [[endocannabinoid system]].
== 5F-AMB ==


==Chemical structure and properties==
[[File:5F-AMB-PINACA.svg|thumb|right|Chemical structure of 5F-AMB]]
5F-AMB is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is (S)-Methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate. The compound features a fluorinated pentyl chain, which is a common modification in synthetic cannabinoids to enhance potency and metabolic stability.


==Pharmacology==
'''5F-AMB''' (also known as '''5F-MMB-PINACA''') is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the [[cannabinoid receptor]]s, specifically the [[CB1 receptor]] and [[CB2 receptor]].
5F-AMB acts as a potent agonist at the CB1 and CB2 receptors, which are G protein-coupled receptors involved in the modulation of neurotransmitter release in the [[central nervous system]] and [[peripheral nervous system]]. The activation of these receptors by 5F-AMB can lead to psychoactive effects similar to those of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].


==Legal status==
=== Chemical Structure ===
Due to its potential for abuse and lack of medical use, 5F-AMB has been classified as a controlled substance in many jurisdictions. It is often included in the list of substances banned under synthetic cannabinoid legislation.


==Health effects==
5F-AMB is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is ''methyl (1-(5-fluoropentyl)-1H-indazole-3-carbonyl)-L-valinate''. The structure of 5F-AMB includes a fluorinated pentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high potency.
The use of 5F-AMB has been associated with a range of adverse health effects, including [[tachycardia]], [[hypertension]], [[nausea]], [[vomiting]], and [[anxiety]]. In severe cases, it can lead to [[psychosis]], [[seizures]], and [[renal failure]].


==Synthesis==
=== Pharmacology ===
The synthesis of 5F-AMB involves the reaction of a fluorinated alkyl chain with an indazole core, followed by the addition of a carboxamide group. The process requires careful control of reaction conditions to ensure the correct stereochemistry and purity of the final product.


==Related pages==
5F-AMB acts as a full agonist at the CB1 and CB2 receptors, which are part of the [[endocannabinoid system]]. This system is involved in regulating various physiological processes, including mood, memory, and pain sensation. The activation of these receptors by 5F-AMB can lead to psychoactive effects similar to those of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].
 
=== Effects and Toxicity ===
 
The effects of 5F-AMB can include euphoria, relaxation, altered perception, and increased appetite. However, due to its high potency, it can also cause severe adverse effects such as anxiety, paranoia, tachycardia, and in some cases, [[psychosis]]. The toxicity of 5F-AMB is not well-documented, but it is believed to be higher than that of natural cannabinoids due to its synthetic nature and high receptor affinity.
 
=== Legal Status ===
 
5F-AMB is classified as a controlled substance in many countries due to its potential for abuse and lack of medical use. It is often included in the list of substances banned under [[analogue drug laws]], which aim to control new psychoactive substances that are chemically similar to already controlled drugs.
 
== Related pages ==
* [[Synthetic cannabinoids]]
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[Cannabinoid receptor]]
* [[Endocannabinoid system]]
* [[Designer drug]]
* [[Designer drug]]
* [[Endocannabinoid system]]
==Gallery==
<gallery>
File:5F-AMB-PINACA.svg|Chemical structure of 5F-AMB
</gallery>


[[Category:Synthetic cannabinoids]]
[[Category:Synthetic cannabinoids]]
[[Category:Designer drugs]]
[[Category:Designer drugs]]

Latest revision as of 04:02, 13 February 2025


5F-AMB[edit]

File:5F-AMB-PINACA.svg
Chemical structure of 5F-AMB

5F-AMB (also known as 5F-MMB-PINACA) is a synthetic cannabinoid that has been used as a designer drug. It is a potent agonist of the cannabinoid receptors, specifically the CB1 receptor and CB2 receptor.

Chemical Structure[edit]

5F-AMB is chemically classified as an indazole-based synthetic cannabinoid. Its full chemical name is methyl (1-(5-fluoropentyl)-1H-indazole-3-carbonyl)-L-valinate. The structure of 5F-AMB includes a fluorinated pentyl chain, which is a common feature in many synthetic cannabinoids, contributing to its high potency.

Pharmacology[edit]

5F-AMB acts as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system. This system is involved in regulating various physiological processes, including mood, memory, and pain sensation. The activation of these receptors by 5F-AMB can lead to psychoactive effects similar to those of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Effects and Toxicity[edit]

The effects of 5F-AMB can include euphoria, relaxation, altered perception, and increased appetite. However, due to its high potency, it can also cause severe adverse effects such as anxiety, paranoia, tachycardia, and in some cases, psychosis. The toxicity of 5F-AMB is not well-documented, but it is believed to be higher than that of natural cannabinoids due to its synthetic nature and high receptor affinity.

Legal Status[edit]

5F-AMB is classified as a controlled substance in many countries due to its potential for abuse and lack of medical use. It is often included in the list of substances banned under analogue drug laws, which aim to control new psychoactive substances that are chemically similar to already controlled drugs.

Related pages[edit]