11-Hydroxycannabinol: Difference between revisions

Latest revision as of 05:20, 16 February 2025

11-Hydroxycannabinol[edit]

11-Hydroxycannabinol (11-OH-CBN) is a cannabinoid metabolite that is formed in the body after the consumption of cannabis. It is a hydroxylated form of cannabinol (CBN), which itself is a degradation product of tetrahydrocannabinol (THC), the primary psychoactive component of cannabis.

Chemical Structure[edit]

11-Hydroxycannabinol is characterized by the addition of a hydroxyl group (-OH) at the 11th carbon position of the CBN molecule. This modification alters the chemical properties and biological activity of the compound compared to its parent molecule, CBN.

Pharmacology[edit]

11-Hydroxycannabinol is known to interact with the endocannabinoid system, specifically binding to cannabinoid receptors such as CB1 and CB2. These interactions can influence various physiological processes, including mood, appetite, and pain perception.

Metabolism[edit]

In the human body, 11-Hydroxycannabinol is produced primarily in the liver through the action of cytochrome P450 enzymes on CBN. This metabolic pathway is similar to the conversion of THC to 11-Hydroxy-THC, another active metabolite.

Biological Effects[edit]

The biological effects of 11-Hydroxycannabinol are not as well-studied as those of THC or CBN. However, it is believed to have a lower psychoactive potency compared to THC. Its effects on the body may include mild sedation and analgesia, but further research is needed to fully understand its pharmacological profile.

Related Compounds[edit]

Related Pages[edit]

@@ Line 1: / Line 1: @@
-{{Short description|A metabolite of THC}}
 {{DISPLAYTITLE:11-Hydroxycannabinol}}
-'''11-Hydroxycannabinol''' (11-OH-CBN) is a [[cannabinoid]] metabolite that is formed in the body after the consumption of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]]. It is one of the many metabolites that result from the metabolic processing of THC in the [[liver]].
+== 11-Hydroxycannabinol ==
+[[File:11-OH-CBN_structure.png|thumb|right|Chemical structure of 11-Hydroxycannabinol]]
+-Hydroxycannabinol (11-OH-CBN) is a [[cannabinoid]] metabolite that is formed in the body after the consumption of [[cannabis]]. It is a hydroxylated form of [[cannabinol]] (CBN), which itself is a degradation product of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of cannabis.
-==Chemical structure and properties==
+== Chemical Structure ==
--Hydroxycannabinol is a hydroxylated form of [[cannabinol]] (CBN). The addition of a hydroxyl group (-OH) to the 11th carbon position of the CBN molecule results in the formation of 11-OH-CBN. This structural modification can influence the compound's [[pharmacokinetics]] and [[pharmacodynamics]].
+-Hydroxycannabinol is characterized by the addition of a hydroxyl group (-OH) at the 11th carbon position of the CBN molecule. This modification alters the chemical properties and biological activity of the compound compared to its parent molecule, CBN.
-==Metabolism==
+== Pharmacology ==
-When THC is consumed, it is metabolized by the liver into various metabolites, including 11-hydroxy-THC and 11-hydroxycannabinol. The enzyme [[cytochrome P450]] plays a significant role in this metabolic process. 11-Hydroxycannabinol is further metabolized into other compounds before being excreted from the body.
+-Hydroxycannabinol is known to interact with the [[endocannabinoid system]], specifically binding to [[cannabinoid receptors]] such as [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]]. These interactions can influence various physiological processes, including mood, appetite, and pain perception.
-==Pharmacology==
+=== Metabolism ===
-The pharmacological effects of 11-hydroxycannabinol are not as well-studied as those of THC or 11-hydroxy-THC. However, it is known that hydroxylated metabolites of cannabinoids can have different affinities for [[cannabinoid receptors]] such as [[CB1 receptor|CB1]] and [[CB2 receptor|CB2]]. These interactions can influence the psychoactive and physiological effects experienced by the user.
+In the human body, 11-Hydroxycannabinol is produced primarily in the [[liver]] through the action of [[cytochrome P450]] enzymes on CBN. This metabolic pathway is similar to the conversion of THC to [[11-Hydroxy-THC]], another active metabolite.
-==Detection in biological samples==
+== Biological Effects ==
--Hydroxycannabinol can be detected in biological samples such as [[blood]] and [[urine]] using various analytical techniques. These techniques are often employed in [[toxicology]] and [[forensic science]] to determine cannabis use.
+The biological effects of 11-Hydroxycannabinol are not as well-studied as those of THC or CBN. However, it is believed to have a lower psychoactive potency compared to THC. Its effects on the body may include mild sedation and analgesia, but further research is needed to fully understand its pharmacological profile.
-==Related pages==
+== Related Compounds ==
-* [[Cannabinoid]]
+* [[Cannabinol]] (CBN)
-* [[Tetrahydrocannabinol]]
+* [[Tetrahydrocannabinol]] (THC)
-* [[Cannabinol]]
 * [[11-Hydroxy-THC]]
+* [[Cannabidiol]] (CBD)
-==Gallery==
+== Related Pages ==
-<gallery>
+* [[Cannabinoid]]
-File:11-OH-CBN_structure.png|Chemical structure of 11-Hydroxycannabinol
+* [[Endocannabinoid system]]
-</gallery>
+* [[Cannabis]]
 [[Category:Cannabinoids]]