OR1F1

OR1F1 is a gene that encodes a protein in humans. It is also known as Olfactory Receptor, Family 1, Subfamily F, Member 1. This gene is part of the olfactory receptor family, which is the largest gene family in the genome. The olfactory receptors olfactory receptors are G protein-coupled receptors that are involved in the detection of smell.

Function

The OR1F1 gene is a member of the olfactory receptor family of genes. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes.

Structure

The OR1F1 gene is located on chromosome 6, specifically at 6p22.1. It spans a length of approximately 1.1 kilobases and consists of a single coding exon. The encoded protein is a member of the Class A rhodopsin-like family of GPCRs, which is characterized by a seven-transmembrane domain structure.

Clinical Significance

While the specific clinical significance of OR1F1 is not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For example, mutations in olfactory receptor genes have been associated with anosmia, which is the inability to perceive smell. Additionally, some olfactory receptors are expressed in tissues other than the olfactory system, suggesting potential roles in other physiological or pathological processes.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia

References

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