OR1M1

OR1M1 is a gene that encodes the olfactory receptor 1M1 in humans. The olfactory receptor family is the largest in the genome. The olfactory receptors (ORs) are G protein-coupled receptors (GPCRs) that play a role in the detection of odor molecules.

Function

The OR1M1 gene is a member of the olfactory receptor family of genes. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes.

Structure

The OR1M1 gene is located on chromosome 1, specifically at 1q44. It spans a length of approximately 1.1 kilobases and consists of a single coding exon. The encoded protein is a member of the Class A rhodopsin-like family of GPCRs, which is characterized by a seven-transmembrane domain structure.

Clinical Significance

While the specific clinical significance of OR1M1 is not yet fully understood, olfactory receptors in general have been implicated in various diseases and conditions. For instance, alterations in the sense of smell, or anosmia, can be an early sign of neurodegenerative diseases like Parkinson's disease and Alzheimer's disease.

Research

Research into the function and potential clinical significance of OR1M1 is ongoing. Understanding the role of this and other olfactory receptors may provide insights into the mechanisms of smell and potential therapeutic targets for conditions affecting the sense of smell.

See Also

• Olfactory receptor
• G protein-coupled receptor
• Anosmia
• Parkinson's disease
• Alzheimer's disease

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