PIAS4

PIAS4 (Protein Inhibitor of Activated STAT 4) is a protein that in humans is encoded by the PIAS4 gene. This protein is a member of the protein inhibitor of activated STAT (PIAS) family. Members of this family function as SUMO E3 ligases and regulate transcriptional activity by modulating the sumoylation status of target proteins.

Function

PIAS4 is a SUMO E3 ligase that facilitates the conjugation of Small Ubiquitin-like Modifier (SUMO) proteins to target substrates. This process, known as sumoylation, is a post-translational modification that alters the function of the substrate protein. PIAS4 preferentially sumoylates Lysine residues in the consensus sequence ΨKXE, where Ψ is a large hydrophobic amino acid, K is lysine, X is any amino acid, and E is glutamic acid.

PIAS4 has been shown to interact with a variety of proteins, including Androgen Receptor (AR), Estrogen Receptor (ER), and p53. Through these interactions, PIAS4 can regulate the transcriptional activity of these proteins.

Clinical significance

Alterations in the PIAS4 gene or protein function have been implicated in several diseases. For example, PIAS4 has been found to be overexpressed in certain types of cancer, and this overexpression has been associated with poor prognosis. In addition, PIAS4 has been implicated in the regulation of immune response, and alterations in PIAS4 function may contribute to the development of autoimmune diseases.

See also

• Protein Inhibitor of Activated STAT
• SUMO E3 ligase
• Sumoylation
• Androgen Receptor
• Estrogen Receptor
• p53

References

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External links

• PIAS4 at the National Center for Biotechnology Information (NCBI)

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