PDBe-KB

PDBe-KB

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PDBe-KB (Protein Data Bank in Europe - Knowledge Base) is a collaborative resource that integrates structural and functional annotations of proteins. It is part of the Protein Data Bank in Europe (PDBe) and is hosted by the European Bioinformatics Institute (EMBL-EBI). PDBe-KB aims to provide a comprehensive view of protein structures by aggregating data from various sources, including experimental data, computational predictions, and community annotations.

Overview

PDBe-KB was established to address the need for a centralized platform that combines structural data with functional annotations. The resource is designed to facilitate the understanding of protein function in the context of their three-dimensional structures. It serves as a hub for researchers, educators, and students in the field of structural biology and bioinformatics.

Features

PDBe-KB offers several features that enhance the usability and accessibility of protein structural data:

• Integrated Annotations: PDBe-KB aggregates annotations from multiple sources, including experimental data from the Protein Data Bank (PDB), computational predictions, and community contributions.

• Functional Annotations: The platform provides detailed functional annotations, such as ligand binding sites, protein-protein interactions, and post-translational modifications.

• Visualization Tools: Users can visualize protein structures and their annotations using interactive 3D viewers, which are integrated into the PDBe-KB interface.

• Search and Retrieval: PDBe-KB offers advanced search capabilities, allowing users to query the database using various criteria, such as protein name, PDB ID, or functional annotation.

Community Involvement

PDBe-KB is a community-driven resource, encouraging contributions from researchers and experts in the field. The platform supports the submission of new annotations and the curation of existing data, fostering a collaborative environment for the continuous improvement of the resource.

Applications

PDBe-KB is widely used in research and education. It supports:

• Structural Biology Research: By providing comprehensive structural and functional data, PDBe-KB aids researchers in understanding protein mechanisms and interactions.

• Drug Discovery: The detailed annotations of ligand binding sites and protein interactions are valuable for drug design and discovery efforts.

• Education: PDBe-KB serves as an educational tool for teaching structural biology and bioinformatics, offering students access to a wealth of annotated protein structures.

Also see

• Protein Data Bank
• European Bioinformatics Institute
• Structural Biology
• Bioinformatics
• Protein Structure

External links

• Official PDBe-KB website

PDBe-KB

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  PDBe-KB logo 2019 black text