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| {{Infobox drug
| | #REDIRECT [[Amphotericin B]] |
| | name = Amphotericin B
| | {{Redirect category shell|1= |
| | image = Amphotericin B structure.svg | | {{R from trade name}} |
| | width = 250
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| | alt =
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| | caption = Chemical structure of Amphotericin B
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| | tradename = Fungizone, others
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| | Drugs.com =
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| | MedlinePlus = a682643
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| | pregnancy_AU = B3
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| | pregnancy_US = B
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| | legal_AU = S4
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| | legal_US = Rx-only
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| | routes_of_administration = Intravenous, topical
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| | bioavailability = Poorly absorbed orally
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| | protein_bound = 95%
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| | metabolism =
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| | elimination_half-life = 15 days
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| | excretion = Bile
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| | CAS_number = 1397-89-3
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| | ATC_prefix = J02
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| | ATC_suffix = AA01
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| | PubChem = 14956
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| | DrugBank = DB00681
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| | ChemSpiderID = 14236
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| | UNII = 7XU7A7DROE
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| | KEGG = D00203
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| | ChEBI = 28920
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| | ChEMBL = 417
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| | C=47
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| | H=73
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| | N=1
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| | O=17
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| | molecular_weight = 924.08 g/mol
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| }} | | }} |
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| '''Amphotericin B''' is an [[antifungal]] medication used for serious fungal infections and leishmaniasis. It is often used for infections such as [[aspergillosis]], [[blastomycosis]], [[candidiasis]], [[coccidioidomycosis]], and [[cryptococcosis]].
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| == Mechanism of Action ==
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| Amphotericin B works by binding to [[ergosterol]], a key component of fungal cell membranes. This binding disrupts the membrane, causing cell contents to leak out, which ultimately leads to cell death. This mechanism is specific to fungi, as ergosterol is not found in human cell membranes.
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| == Administration ==
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| Amphotericin B is typically administered intravenously due to its poor oral absorption. It is available in several formulations, including conventional amphotericin B deoxycholate and lipid formulations such as liposomal amphotericin B, which are designed to reduce toxicity.
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| == Side Effects ==
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| Common side effects of amphotericin B include fever, chills, and headache. More serious side effects can include kidney damage, electrolyte imbalances, and infusion-related reactions. Lipid formulations are associated with fewer side effects compared to the conventional form.
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| == Clinical Uses ==
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| Amphotericin B is used in the treatment of severe systemic fungal infections. It is often reserved for life-threatening infections due to its potential toxicity. It is also used in the treatment of certain protozoal infections, such as visceral leishmaniasis.
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| == History ==
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| Amphotericin B was discovered in 1955 and was originally isolated from the bacterium ''[[Streptomyces nodosus]]''. It has been a critical drug in the treatment of fungal infections for decades, despite its side effects.
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| == See Also ==
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| * [[Antifungal drug]]
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| * [[Fungal infection]]
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| * [[Liposomal amphotericin B]]
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| == References ==
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| * {{cite journal |last1=Walsh |first1=Thomas J. |last2=Finberg |first2=Robert W. |title=Amphotericin B: Mechanism of Action and Resistance |journal=Clinical Infectious Diseases |volume=22 |issue=2 |year=1996 |pages=S97–S110 |doi=10.1093/clinids/22.Supplement_2.S97}}
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| * {{cite book |last=Kauffman |first=Carol A. |title=Fungal Infections: Diagnosis and Management |publisher=Springer |year=2006 |isbn=978-1-85233-905-8}}
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| == External Links ==
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| * [https://www.drugs.com/monograph/amphotericin-b.html Drugs.com: Amphotericin B]
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| * [https://www.mayoclinic.org/drugs-supplements/amphotericin-b-intravenous-route/description/drg-20061816 Mayo Clinic: Amphotericin B]
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| [[Category:Antifungal agents]]
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| [[Category:Polyenes]]
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| [[Category:World Health Organization essential medicines]]
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