Immunodeficiency 26: Difference between revisions

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'''Immunodeficiency 26''' is a rare genetic disorder that affects the immune system, leading to increased susceptibility to infections and potentially other immune-related issues. This condition is part of a broader category of diseases known as [[primary immunodeficiencies]], which are disorders where the immune system's ability to fight off infections is compromised due to genetic abnormalities.
{{SI}}
 
{{Infobox medical condition
==Causes==
| name            = Immunodeficiency 26
Immunodeficiency 26 is caused by mutations in a specific gene that is crucial for the normal development and function of the immune system. The exact gene and the nature of the mutations can vary among individuals, which can lead to variability in the severity and specific symptoms of the disorder.
| image          = [[File:Autorecessive.svg|200px]]
 
| caption        = Autosomal recessive pattern
==Symptoms==
| field          = [[Immunology]]
The primary symptom of Immunodeficiency 26 is an increased susceptibility to infections, including bacterial, viral, and fungal infections. These infections can be more frequent, severe, and harder to treat than in individuals with a normal immune system. Other symptoms may include autoimmunity, where the immune system attacks the body's own tissues, and an increased risk of developing certain types of cancers.
| symptoms        = Recurrent [[infections]], [[autoimmune disorders]]
 
| complications  = Increased risk of [[cancer]]
==Diagnosis==
| onset          = Childhood
Diagnosis of Immunodeficiency 26 typically involves a combination of clinical evaluation, family history, and genetic testing. Genetic testing can confirm the presence of mutations associated with the disorder and help guide treatment and management decisions.
| duration        = Lifelong
 
| causes          = Genetic mutations in the [[SP110]] gene
==Treatment==
| risks          = Family history of the condition
Treatment for Immunodeficiency 26 focuses on managing symptoms and preventing infections. This may include the use of antibiotics, antiviral, and antifungal medications to treat and prevent infections. Immunoglobulin replacement therapy may also be used to boost the immune system. In some cases, bone marrow or stem cell transplantation may be considered as a potential cure for the disorder.
| diagnosis      = [[Genetic testing]], [[blood tests]]
 
| differential    = Other forms of [[immunodeficiency]]
==Prognosis==
| treatment      = [[Immunoglobulin therapy]], [[antibiotics]], [[hematopoietic stem cell transplantation]]
The prognosis for individuals with Immunodeficiency 26 varies depending on the severity of the disorder and the effectiveness of treatment. With appropriate management, many individuals can lead relatively normal lives. However, there is an increased risk of chronic health issues and early mortality due to complications from infections and other immune-related problems.
| prognosis      = Variable, depending on severity and treatment
 
| frequency      = Rare
}}
'''Immunodeficiency''' is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either [[primary immunodeficiency|primary]] or [[secondary immunodeficiency|secondary]].
== Types of Immunodeficiency ==
=== Primary Immunodeficiency ===
Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an [[autosomal recessive]] pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including [[B cells]], [[T cells]], and [[complement system|complement proteins]].
=== Secondary Immunodeficiency ===
Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include [[HIV/AIDS]], [[malnutrition]], and certain medical treatments such as [[chemotherapy]] and [[immunosuppressive drugs]].
== Symptoms ==
Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include:
* Recurrent [[pneumonia]]
* Chronic [[sinusitis]]
* Persistent [[diarrhea]]
* Skin infections
== Diagnosis ==
Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include:
* Complete blood count (CBC)
* Quantitative immunoglobulins
* Specific antibody response tests
* Genetic testing for primary immunodeficiencies
== Treatment ==
Treatment depends on the type and severity of the immunodeficiency. Options may include:
* [[Antibiotics]] to treat infections
* [[Immunoglobulin therapy]]
* [[Bone marrow transplant]] for severe cases
* Lifestyle modifications to reduce infection risk
== See also ==
* [[Immune system]]
* [[Autoimmune disease]]
* [[HIV/AIDS]]
* [[Vaccination]]
[[Category:Immunology]]
[[Category:Genetic disorders]]
[[Category:Genetic disorders]]
[[Category:Immune system disorders]]
{{Medicine-stub}}

Latest revision as of 21:27, 6 April 2025

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
Founder, WikiMD Wellnesspedia &
W8MD medical weight loss NYC and sleep center NYC

Immunodeficiency 26
Synonyms N/A
Pronounce N/A
Specialty N/A
Symptoms Recurrent infections, autoimmune disorders
Complications Increased risk of cancer
Onset Childhood
Duration Lifelong
Types N/A
Causes Genetic mutations in the SP110 gene
Risks Family history of the condition
Diagnosis Genetic testing, blood tests
Differential diagnosis Other forms of immunodeficiency
Prevention N/A
Treatment Immunoglobulin therapy, antibiotics, hematopoietic stem cell transplantation
Medication N/A
Prognosis Variable, depending on severity and treatment
Frequency Rare
Deaths N/A


Immunodeficiency is a state in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. Immunodeficiencies can be classified as either primary or secondary.

Types of Immunodeficiency[edit]

Primary Immunodeficiency[edit]

Primary immunodeficiencies are usually genetic and present at birth. They are often inherited in an autosomal recessive pattern, as depicted in the diagram. These conditions are rare and can affect various components of the immune system, including B cells, T cells, and complement proteins.

Secondary Immunodeficiency[edit]

Secondary immunodeficiencies are acquired later in life and are more common than primary immunodeficiencies. Causes include HIV/AIDS, malnutrition, and certain medical treatments such as chemotherapy and immunosuppressive drugs.

Symptoms[edit]

Individuals with immunodeficiency may experience frequent and severe infections, which can be recurrent and difficult to treat. Common symptoms include:

Diagnosis[edit]

Diagnosis of immunodeficiency involves a combination of clinical evaluation and laboratory tests. These may include:

  • Complete blood count (CBC)
  • Quantitative immunoglobulins
  • Specific antibody response tests
  • Genetic testing for primary immunodeficiencies

Treatment[edit]

Treatment depends on the type and severity of the immunodeficiency. Options may include:

See also[edit]

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