Mannose receptor

Mannose Receptor

The Mannose Receptor (MR, CD206) is a C-type lectin receptor expressed primarily by macrophages, dendritic cells, and certain endothelial cells. It plays a crucial role in the immune system by recognizing and binding to specific carbohydrate structures, including mannose, fucose, and N-acetylglucosamine, found on the surface of pathogens such as bacteria, fungi, and viruses. This recognition facilitates the phagocytosis and clearance of these pathogens, thereby contributing to the body's innate immune response.

Structure

The Mannose Receptor is a type I transmembrane protein composed of multiple domains: an N-terminal cysteine-rich domain, a fibronectin type II domain, eight C-type lectin-like domains (CTLDs), a transmembrane domain, and a short cytoplasmic tail. The CTLDs are responsible for the recognition and binding of carbohydrate structures.

Function

The primary function of the Mannose Receptor is to mediate the endocytosis of glycoproteins by macrophages. It recognizes carbohydrate patterns found on the surface of many pathogens and damaged cells, facilitating their uptake and removal from the body. Additionally, the Mannose Receptor is involved in antigen presentation. By capturing antigens and presenting them to T cells, it plays a role in initiating and shaping the adaptive immune response.

Beyond its role in immunity, the Mannose Receptor is involved in homeostatic processes such as the clearance of glycoproteins from the bloodstream and the remodeling of extracellular matrix components.

Clinical Significance

Alterations in the expression or function of the Mannose Receptor have been implicated in various diseases. Overexpression can contribute to the pathogenesis of allergic and autoimmune diseases by enhancing the uptake and presentation of antigens. Conversely, reduced expression may impair the immune system's ability to clear pathogens, leading to increased susceptibility to infections.

The Mannose Receptor is also being explored as a target for therapeutic interventions. Its ability to recognize and bind specific carbohydrate structures has been utilized in the development of targeted drug delivery systems, aiming to enhance the efficacy and reduce the side effects of treatments for diseases such as cancer and autoimmune disorders.

Research Directions

Current research on the Mannose Receptor focuses on elucidating its role in disease mechanisms and exploring its potential as a therapeutic target. Studies are investigating the receptor's involvement in diseases beyond its traditional roles in infection and immunity, including cancer, metabolic disorders, and neurodegenerative diseases.

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  Mannose receptor domain organisation
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  Mannose receptor Cys-rich domain