Jatrorrhizine: Difference between revisions

Latest revision as of 11:33, 15 February 2025

Jatrorrhizine[edit]

Jatrorrhizine is a protoberberine alkaloid found in several plant species, particularly those belonging to the family Menispermaceae. It is known for its potential pharmacological properties, including antimicrobial, anti-inflammatory, and antidiabetic effects.

Chemical Structure[edit]

Jatrorrhizine is a quaternary ammonium salt with a complex structure characterized by a tetracyclic ring system. The chemical formula of jatrorrhizine is C20H20NO4. Its structure is similar to other protoberberine alkaloids such as berberine and palmatine.

Sources[edit]

Jatrorrhizine is primarily extracted from plants such as Coptis chinensis (Chinese goldthread), Berberis vulgaris (barberry), and Tinospora cordifolia (Guduchi). These plants have been used in traditional medicine systems like Traditional Chinese Medicine and Ayurveda.

Pharmacological Properties[edit]

Antimicrobial Activity[edit]

Jatrorrhizine exhibits significant antimicrobial properties. It has been shown to inhibit the growth of various bacteria and fungi, making it a potential candidate for developing new antimicrobial agents.

Anti-inflammatory Effects[edit]

Studies suggest that jatrorrhizine can modulate inflammatory pathways, reducing the production of pro-inflammatory cytokines. This makes it a compound of interest for treating inflammatory conditions.

Antidiabetic Potential[edit]

Jatrorrhizine has been investigated for its ability to improve glucose metabolism and insulin sensitivity, indicating its potential use in managing diabetes mellitus.

Mechanism of Action[edit]

The exact mechanism of action of jatrorrhizine is not fully understood. However, it is believed to interact with various cellular targets, including enzymes and receptors involved in metabolic and inflammatory pathways.

Safety and Toxicity[edit]

While jatrorrhizine is generally considered safe at low doses, high doses may lead to toxicity. Further research is needed to fully understand its safety profile and potential side effects.

Related Pages[edit]

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-'''Jatrorrhizine''' is an [[alkaloid]] found in several plant species, including those in the [[Berberis]] and [[Coptis]] genera. It is a protoberberine alkaloid, a class of compounds with a wide range of biological activities.
+== Jatrorrhizine ==
-==Chemistry==
+[[File:Jatrorrhizine.svg|thumb|right|Chemical structure of Jatrorrhizine]]
-Jatrorrhizine is a [[protoberberine]] alkaloid, a type of [[isoquinoline]] alkaloid. It has a molecular formula of C20H20NO4+ and a molar mass of 342.38 g/mol. The compound is structurally similar to other protoberberine alkaloids, such as [[berberine]] and [[palmatine]], with the primary difference being the presence of a methylenedioxy group on the D ring.
-==Sources==
+'''Jatrorrhizine''' is a protoberberine alkaloid found in several plant species, particularly those belonging to the family [[Menispermaceae]]. It is known for its potential pharmacological properties, including antimicrobial, anti-inflammatory, and antidiabetic effects.
-Jatrorrhizine is found in several plant species, most notably those in the Berberis and Coptis genera. Other sources include [[Phellodendron amurense]], [[Corydalis yanhusuo]], and [[Tinospora cordifolia]]. The compound is typically isolated from the roots or bark of these plants.
-==Biological Activity==
+== Chemical Structure ==
-Jatrorrhizine exhibits a wide range of biological activities. It has been shown to have [[antimicrobial]] properties, with activity against a variety of bacteria and fungi. The compound also has [[antioxidant]] activity and can protect cells from oxidative stress. In addition, jatrorrhizine has been found to have [[anti-inflammatory]] effects and can inhibit the production of pro-inflammatory cytokines.
-==Medical Uses==
+Jatrorrhizine is a quaternary ammonium salt with a complex structure characterized by a tetracyclic ring system. The chemical formula of jatrorrhizine is C20H20NO4. Its structure is similar to other protoberberine alkaloids such as [[berberine]] and [[palmatine]].
-While jatrorrhizine is not currently used as a drug, it has potential for use in several medical applications. Its antimicrobial and anti-inflammatory properties make it a potential candidate for the treatment of infections and inflammatory conditions. Additionally, the compound's antioxidant activity could make it useful in the treatment of diseases associated with oxidative stress, such as [[cardiovascular disease]] and [[neurodegenerative disease]]s.
-==Research==
+== Sources ==
-Research into the potential medical uses of jatrorrhizine is ongoing. Studies have shown that the compound has potential as a treatment for [[diabetes]], due to its ability to inhibit the enzyme [[alpha-glucosidase]], which is involved in carbohydrate digestion. Other research has focused on the compound's potential as a treatment for [[cancer]], due to its ability to induce apoptosis in cancer cells.
+Jatrorrhizine is primarily extracted from plants such as [[Coptis chinensis]] (Chinese goldthread), [[Berberis vulgaris]] (barberry), and [[Tinospora cordifolia]] (Guduchi). These plants have been used in traditional medicine systems like [[Traditional Chinese Medicine]] and [[Ayurveda]].
+== Pharmacological Properties ==
+=== Antimicrobial Activity ===
+Jatrorrhizine exhibits significant antimicrobial properties. It has been shown to inhibit the growth of various [[bacteria]] and [[fungi]], making it a potential candidate for developing new antimicrobial agents.
+=== Anti-inflammatory Effects ===
+Studies suggest that jatrorrhizine can modulate inflammatory pathways, reducing the production of pro-inflammatory cytokines. This makes it a compound of interest for treating inflammatory conditions.
+=== Antidiabetic Potential ===
+Jatrorrhizine has been investigated for its ability to improve glucose metabolism and insulin sensitivity, indicating its potential use in managing [[diabetes mellitus]].
+== Mechanism of Action ==
+The exact mechanism of action of jatrorrhizine is not fully understood. However, it is believed to interact with various cellular targets, including enzymes and receptors involved in metabolic and inflammatory pathways.
+== Safety and Toxicity ==
+While jatrorrhizine is generally considered safe at low doses, high doses may lead to toxicity. Further research is needed to fully understand its safety profile and potential side effects.
+== Related Pages ==
-==See Also==
 * [[Berberine]]
-* [[Coptis]]
+* [[Palmatine]]
-* [[Protoberberine alkaloids]]
+* [[Coptis chinensis]]
+* [[Traditional Chinese Medicine]]
 [[Category:Alkaloids]]
-[[Category:Phytochemicals]]
+[[Category:Pharmacology]]
-[[Category:Medicinal plants]]
+[[Category:Chemical compounds]]
-{{medicine-stub}}