OR4C12: Difference between revisions

OR4C12
Symbol	OR4C12
HGNC ID	8180
Alternative symbols	–
Entrez Gene	–
OMIM	–
RefSeq	–
UniProt	–
Chromosome	11q11.2
Locus supplementary data	–

Latest revision as of 20:35, 30 December 2024

OR4C12 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the G protein-coupled receptor (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of smell.

Function[edit]

The OR4C12 gene is involved in the detection of odorant molecules in the olfactory system. Olfactory receptors, including OR4C12, are located in the olfactory epithelium of the nasal cavity. They interact with odorant molecules to initiate a neuronal response that is transmitted to the olfactory bulb in the brain, leading to the perception of smell.

Structure[edit]

Olfactory receptors like OR4C12 share a common structure with other GPCRs, characterized by seven transmembrane domains. This structure allows them to traverse the cell membrane and interact with G proteins inside the cell, which then trigger a cascade of intracellular events.

Genetic Information[edit]

The OR4C12 gene is located on chromosome 11 at the q11.2 band. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. These genes are highly diverse, allowing humans to detect a wide range of odors.

Clinical Significance[edit]

While the primary function of OR4C12 is related to olfaction, variations in olfactory receptor genes can influence individual differences in smell perception. However, specific clinical conditions directly associated with OR4C12 have not been extensively documented.

References[edit]

External Links[edit]

@@ Line 1: / Line 1: @@
-'''OR4C12''' is a gene that encodes a protein in the olfactory receptor family. This family is a group of [[G protein-coupled receptors]] which are responsible for detecting molecules in the environment and subsequently initiating a neuronal response. The olfactory receptor proteins interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.
+{{Infobox gene
+| name = OR4C12
+| symbol = OR4C12
+| HGNCid = 8180
+| chromosome = 11
+| arm = q
+| band = 11.2
+| locus = 11q11.2
+}}
+'''OR4C12''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are part of the [[G protein-coupled receptor]] (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of [[smell]].
 == Function ==
+The OR4C12 gene is involved in the detection of odorant molecules in the [[olfactory system]]. Olfactory receptors, including OR4C12, are located in the [[olfactory epithelium]] of the [[nasal cavity]]. They interact with odorant molecules to initiate a neuronal response that is transmitted to the [[olfactory bulb]] in the [[brain]], leading to the perception of smell.
-The olfactory receptor family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. The OR4C12 gene is a member of the olfactory receptor family, and like other members of this family, it is believed to function in the detection of odorants.
 == Structure ==
+Olfactory receptors like OR4C12 share a common structure with other GPCRs, characterized by seven transmembrane domains. This structure allows them to traverse the [[cell membrane]] and interact with [[G proteins]] inside the cell, which then trigger a cascade of intracellular events.
-The OR4C12 gene is located on chromosome 11, specifically at 11p15.4. It spans approximately 1.1 kilobases and consists of a single exon. The OR4C12 protein is a member of the class A rhodopsin-like family of G protein-coupled receptors. It is composed of 312 amino acids and has a predicted molecular weight of approximately 35 kDa.
+== Genetic Information ==
+The OR4C12 gene is located on [[chromosome 11]] at the q11.2 band. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. These genes are highly diverse, allowing humans to detect a wide range of odors.
 == Clinical Significance ==
+While the primary function of OR4C12 is related to olfaction, variations in olfactory receptor genes can influence individual differences in smell perception. However, specific clinical conditions directly associated with OR4C12 have not been extensively documented.
-While the specific role of OR4C12 in human health and disease is not yet fully understood, olfactory receptors in general have been implicated in a variety of physiological and pathological processes. These include roles in immunity, reproduction, and disease detection. Further research is needed to elucidate the specific functions and potential clinical relevance of OR4C12.
-[[File:OR4C12 gene location on human chromosome 11.png|thumb|right|300px|Location of the OR4C12 gene on human chromosome 11.]]
 == See Also ==
+* [[Olfactory receptor family]]
-* [[Olfactory receptor]]
 * [[G protein-coupled receptor]]
-* [[Chromosome 11 (human)]]
+* [[Olfactory system]]
 == References ==
+{{Reflist}}
-<references />
+== External Links ==
+* [https://www.ncbi.nlm.nih.gov/gene/OR4C12 OR4C12 Gene - NCBI]
+* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR4C12 OR4C12 Gene - GeneCards]
-{{G protein-coupled receptors}}
+[[Category:Olfactory receptors]]
-{{Human chromosome 11}}
-{{medicine-stub}}
-[[Category:Genes on human chromosome 11]]
 [[Category:G protein-coupled receptors]]
-[[Category:Olfactory receptors]]
+[[Category:Human genes]]