OR5U1: Difference between revisions
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'''OR5U1''' is a gene that encodes | |||
{{Infobox gene | |||
| name = OR5U1 | |||
| symbol = OR5U1 | |||
| HGNCid = 14857 | |||
| chromosome = 11 | |||
| arm = q | |||
| band = 11.2 | |||
| locus = 11q11.2 | |||
| gene_family = Olfactory receptor | |||
}} | |||
'''OR5U1''' is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the [[G protein-coupled receptor]] (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of [[smell]]. | |||
== Function == | == Function == | ||
Olfactory receptors, such as OR5U1, are expressed in the [[olfactory epithelium]] and are involved in the detection of odorants. These receptors interact with odorant molecules in the [[nasal cavity]], leading to the activation of a G protein-mediated signal transduction pathway. This ultimately results in a neuronal response that is perceived as a distinct smell by the brain. | |||
== Structure == | == Structure == | ||
OR5U1, like other olfactory receptors, has a 7-transmembrane domain structure typical of GPCRs. This structure allows the receptor to traverse the [[cell membrane]] and interact with intracellular G proteins. | |||
== Genetic Information == | |||
The OR5U1 gene is located on chromosome 11 at the q11.2 locus. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell. | |||
== Clinical Significance == | == Clinical Significance == | ||
While | While specific clinical implications of OR5U1 are not well-documented, variations in olfactory receptor genes can affect an individual's sense of smell. This can have implications for [[anosmia]] (loss of smell) or [[hyposmia]] (reduced sense of smell), which can impact quality of life and may be associated with certain neurological conditions. | ||
== Research == | |||
Research into olfactory receptors like OR5U1 continues to provide insights into the molecular mechanisms of olfaction and its role in human health and disease. Understanding these receptors can also contribute to the development of artificial sensing devices and novel therapeutic approaches. | |||
== See Also == | == See Also == | ||
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* [[G protein-coupled receptor]] | * [[G protein-coupled receptor]] | ||
* [[Anosmia]] | * [[Anosmia]] | ||
* [[Hyposmia]] | |||
== References == | == References == | ||
<references /> | <references/> | ||
== External Links == | |||
* [https://www.ncbi.nlm.nih.gov/gene/OR5U1 OR5U1 Gene - NCBI] | |||
* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR5U1 OR5U1 Gene - GeneCards] | |||
[[Category:Genes on human chromosome | [[Category:Genes on human chromosome 11]] | ||
[[Category:Olfactory receptors]] | [[Category:Olfactory receptors]] | ||
[[Category:G protein-coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
Latest revision as of 20:27, 30 December 2024
| Symbol | OR5U1 |
|---|---|
| HGNC ID | 14857 |
| Alternative symbols | – |
| Entrez Gene | – |
| OMIM | – |
| RefSeq | – |
| UniProt | – |
| Chromosome | 11q11.2 |
| Locus supplementary data | – |
OR5U1 is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are part of the G protein-coupled receptor (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of smell.
Function[edit]
Olfactory receptors, such as OR5U1, are expressed in the olfactory epithelium and are involved in the detection of odorants. These receptors interact with odorant molecules in the nasal cavity, leading to the activation of a G protein-mediated signal transduction pathway. This ultimately results in a neuronal response that is perceived as a distinct smell by the brain.
Structure[edit]
OR5U1, like other olfactory receptors, has a 7-transmembrane domain structure typical of GPCRs. This structure allows the receptor to traverse the cell membrane and interact with intracellular G proteins.
Genetic Information[edit]
The OR5U1 gene is located on chromosome 11 at the q11.2 locus. It is part of a large family of olfactory receptor genes that are distributed throughout the human genome. The olfactory receptor gene family is the largest in the human genome, highlighting the complexity and diversity of the sense of smell.
Clinical Significance[edit]
While specific clinical implications of OR5U1 are not well-documented, variations in olfactory receptor genes can affect an individual's sense of smell. This can have implications for anosmia (loss of smell) or hyposmia (reduced sense of smell), which can impact quality of life and may be associated with certain neurological conditions.
Research[edit]
Research into olfactory receptors like OR5U1 continues to provide insights into the molecular mechanisms of olfaction and its role in human health and disease. Understanding these receptors can also contribute to the development of artificial sensing devices and novel therapeutic approaches.
See Also[edit]
References[edit]
<references/>
