FOXQ1: Difference between revisions

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'''FOXQ1''' is a gene that encodes a member of the FOX family of transcription factors. The FOX family is a large group of proteins that share a common DNA-binding domain known as the forkhead box or winged-helix domain. The FOXQ1 gene is located on chromosome 6q25.3 and is expressed in a variety of tissues, including the brain, heart, and kidneys.
 
{{Infobox gene
| name = FOXQ1
| symbol = FOXQ1
| HGNCid = 3803
| OMIM = 603252
| EntrezGene = 94234
| RefSeq = NM_033260
| UniProt = Q9C009
| chromosome = 6
| arm = p
| band = 25.3
}}
 
'''FOXQ1''' is a member of the [[forkhead box]] (FOX) family of [[transcription factors]]. These proteins are characterized by a distinct [[forkhead domain]], which is a type of [[DNA-binding domain]]. The FOXQ1 gene is located on [[chromosome 6]] at the p25.3 band.


== Function ==
== Function ==
The [[FOXQ1]] gene is involved in a wide range of biological processes, including cell growth, differentiation, and longevity. It is also implicated in the development of several types of cancer, including breast, lung, and colorectal cancer. The protein encoded by this gene can act as a transcriptional repressor or activator, depending on the context.
FOXQ1 plays a crucial role in the regulation of [[gene expression]] during [[development]] and [[cell differentiation]]. It is involved in various biological processes, including [[epithelial-mesenchymal transition]] (EMT), which is important for [[embryogenesis]], [[tissue repair]], and [[cancer metastasis]].
 
== Clinical significance ==
Alterations in the expression of the FOXQ1 gene have been associated with a number of diseases. For example, overexpression of FOXQ1 has been observed in several types of cancer, including [[breast cancer]], [[lung cancer]], and [[colorectal cancer]]. In these cancers, high levels of FOXQ1 are often associated with poor prognosis.  


In addition to its role in cancer, FOXQ1 has also been implicated in other diseases. For example, mutations in the FOXQ1 gene have been associated with [[Rett syndrome]], a rare genetic disorder that affects brain development in girls.
== Clinical Significance ==
Alterations in FOXQ1 expression have been associated with several types of [[cancer]], including [[colorectal cancer]], [[breast cancer]], and [[gastric cancer]]. Overexpression of FOXQ1 can lead to increased [[tumorigenicity]] and [[metastatic potential]] of cancer cells.


== Research ==
== Research ==
Research into the function and regulation of the FOXQ1 gene is ongoing. Current areas of focus include understanding how FOXQ1 contributes to cancer development and progression, and identifying potential therapeutic targets for diseases associated with alterations in FOXQ1 expression.
Studies have shown that FOXQ1 can interact with other signaling pathways, such as the [[Wnt signaling pathway]], to promote cancer progression. It is also a potential target for [[therapeutic intervention]] in cancer treatment.
 
[[File:FOXQ1 gene location on human chromosome 6.png|thumb|right|300px|Location of the FOXQ1 gene on human chromosome 6.]]


== See also ==
== See Also ==
* [[Forkhead box protein]]
* [[Forkhead box protein]]
* [[Transcription factor]]
* [[Transcription factor]]
* [[Cancer]]
* [[Gene expression]]
* [[Rett syndrome]]
* [[Cancer biology]]


== References ==
== References ==
<references />
{{Reflist}}


{{medicine-stub}}
== External Links ==
* [https://www.ncbi.nlm.nih.gov/gene/94234 FOXQ1 Gene - NCBI]
* [https://www.uniprot.org/uniprot/Q9C009 FOXQ1 Protein - UniProt]


[[Category:Genes]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
[[Category:Cancer]]
[[Category:Genes on human chromosome 6]]
[[Category:Rett syndrome]]
[[Category:Forkhead transcription factors]]
[[Category:Cancer research]]

Latest revision as of 17:33, 30 December 2024


FOXQ1
Symbol FOXQ1
HGNC ID 3803
Alternative symbols –
Entrez Gene 94234
OMIM 603252
RefSeq NM_033260
UniProt Q9C009
Chromosome 6p25.3
Locus supplementary data –


FOXQ1 is a member of the forkhead box (FOX) family of transcription factors. These proteins are characterized by a distinct forkhead domain, which is a type of DNA-binding domain. The FOXQ1 gene is located on chromosome 6 at the p25.3 band.

Function[edit]

FOXQ1 plays a crucial role in the regulation of gene expression during development and cell differentiation. It is involved in various biological processes, including epithelial-mesenchymal transition (EMT), which is important for embryogenesis, tissue repair, and cancer metastasis.

Clinical Significance[edit]

Alterations in FOXQ1 expression have been associated with several types of cancer, including colorectal cancer, breast cancer, and gastric cancer. Overexpression of FOXQ1 can lead to increased tumorigenicity and metastatic potential of cancer cells.

Research[edit]

Studies have shown that FOXQ1 can interact with other signaling pathways, such as the Wnt signaling pathway, to promote cancer progression. It is also a potential target for therapeutic intervention in cancer treatment.

See Also[edit]

References[edit]

<references group="" responsive="1"></references>


External Links[edit]

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