Verosudil: Difference between revisions
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'''Verosudil''' is a [[ | {{DISPLAYTITLE:Verosudil}} | ||
== Overview == | |||
'''Verosudil''' is a [[pharmaceutical drug]] that acts as a [[Rho kinase inhibitor]]. It is primarily used in the treatment of [[ocular hypertension]] and [[glaucoma]]. By inhibiting the Rho kinase pathway, Verosudil helps to lower intraocular pressure, which is a major risk factor for glaucoma. | |||
== Mechanism of Action == | == Mechanism of Action == | ||
Verosudil works by inhibiting the activity of [[Rho-associated protein kinase]] (ROCK), which is involved in the regulation of the [[cytoskeleton]] and cellular contraction. Inhibition of ROCK leads to relaxation of the [[trabecular meshwork]] and increased outflow of [[aqueous humor]] through the [[Schlemm's canal]], thereby reducing intraocular pressure. | |||
[[Verosudil]] | == Chemical Structure == | ||
[[File:Verosudil_structure.png|thumb|right|Chemical structure of Verosudil]] | |||
The chemical structure of Verosudil is characterized by its unique arrangement of atoms that allow it to effectively inhibit Rho kinase. The molecular formula and specific stereochemistry contribute to its pharmacological activity. | |||
== Clinical Use == | == Clinical Use == | ||
Verosudil is administered as an [[ophthalmic solution]] and is typically prescribed for patients with [[open-angle glaucoma]] or [[ocular hypertension]] who require additional intraocular pressure reduction. It is often used in combination with other [[antiglaucoma medications]] to achieve optimal results. | |||
[[ | |||
== Side Effects == | == Side Effects == | ||
Common side effects of Verosudil include [[conjunctival hyperemia]], [[corneal verticillata]], and mild [[ocular irritation]]. These side effects are generally mild and transient. Patients are advised to report any severe or persistent symptoms to their healthcare provider. | |||
== Related Pages == | |||
== | |||
* [[Glaucoma]] | * [[Glaucoma]] | ||
* [[Ocular hypertension]] | * [[Ocular hypertension]] | ||
* [[Rho kinase]] | |||
* [[Aqueous humor]] | |||
[[Category:Pharmaceutical drugs]] | |||
[[Category: | |||
[[Category:Ophthalmology]] | [[Category:Ophthalmology]] | ||
Latest revision as of 12:06, 15 February 2025
Overview[edit]
Verosudil is a pharmaceutical drug that acts as a Rho kinase inhibitor. It is primarily used in the treatment of ocular hypertension and glaucoma. By inhibiting the Rho kinase pathway, Verosudil helps to lower intraocular pressure, which is a major risk factor for glaucoma.
Mechanism of Action[edit]
Verosudil works by inhibiting the activity of Rho-associated protein kinase (ROCK), which is involved in the regulation of the cytoskeleton and cellular contraction. Inhibition of ROCK leads to relaxation of the trabecular meshwork and increased outflow of aqueous humor through the Schlemm's canal, thereby reducing intraocular pressure.
Chemical Structure[edit]
The chemical structure of Verosudil is characterized by its unique arrangement of atoms that allow it to effectively inhibit Rho kinase. The molecular formula and specific stereochemistry contribute to its pharmacological activity.
Clinical Use[edit]
Verosudil is administered as an ophthalmic solution and is typically prescribed for patients with open-angle glaucoma or ocular hypertension who require additional intraocular pressure reduction. It is often used in combination with other antiglaucoma medications to achieve optimal results.
Side Effects[edit]
Common side effects of Verosudil include conjunctival hyperemia, corneal verticillata, and mild ocular irritation. These side effects are generally mild and transient. Patients are advised to report any severe or persistent symptoms to their healthcare provider.
