XCT-790: Difference between revisions

Latest revision as of 04:05, 13 February 2025

XCT-790[edit]

XCT-790 is a chemical compound known for its role as a selective inverse agonist of the estrogen-related receptor alpha (ERR_). It is primarily used in research settings to study the function of ERR_, a member of the nuclear receptor family of intracellular transcription factors.

Mechanism of Action[edit]

XCT-790 functions by binding to the ligand-binding domain of ERR_, thereby inhibiting its activity. ERR_ is an orphan nuclear receptor, meaning it does not have a known endogenous ligand. XCT-790's ability to act as an inverse agonist makes it a valuable tool for investigating the physiological and pathological roles of ERR_ in various tissues.

Biological Significance[edit]

ERR_ is involved in the regulation of energy metabolism, mitochondrial biogenesis, and oxidative phosphorylation. It is highly expressed in tissues with high energy demands, such as the heart, skeletal muscle, and brown adipose tissue. By modulating ERR_ activity, XCT-790 can influence metabolic pathways and has been used to study conditions such as obesity, diabetes, and cancer.

Research Applications[edit]

XCT-790 is utilized in laboratory research to:

Investigate the role of ERR_ in metabolic disorders.
Study the effects of ERR_ inhibition on cancer cell proliferation and survival.
Explore the potential therapeutic applications of ERR_ modulation in cardiovascular diseases.

Safety and Handling[edit]

As with many research chemicals, XCT-790 should be handled with care. Appropriate safety protocols should be followed, including the use of personal protective equipment (PPE) and working in a well-ventilated area or fume hood.

Related Pages[edit]

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-'''XCT-790''' is a synthetic compound that acts as an [[inverse agonist]] for the [[Estrogen-related receptor alpha]] (ERRα). ERRα is a member of the nuclear receptor family of intracellular transcription factors and is closely related to the estrogen receptor, although it does not respond to estrogen. XCT-790 is used in scientific research to explore the role of ERRα in biology and medicine.
+== XCT-790 ==
-==Chemistry==
+[[File:XCT790-A.png|thumb|right|Chemical structure of XCT-790]]
-XCT-790 is a small molecule with a molecular weight of 394.4 g/mol. It is a synthetic compound, meaning it is not found naturally but is produced in a laboratory. The chemical formula of XCT-790 is C_24H_17F_3O_2.
-==Mechanism of Action==
+'''XCT-790''' is a chemical compound known for its role as a selective inverse agonist of the [[estrogen-related receptor alpha]] (ERR_). It is primarily used in research settings to study the function of ERR_, a member of the nuclear receptor family of intracellular transcription factors.
-XCT-790 functions as an inverse agonist for ERRα. An [[inverse agonist]] is a type of drug that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist. In the case of XCT-790, it binds to ERRα and inhibits its activity. This is in contrast to an agonist for ERRα, which would increase its activity.
-==Uses in Research==
+== Mechanism of Action ==
-XCT-790 is primarily used in scientific research to study the role of ERRα. ERRα is involved in many biological processes, including energy homeostasis, cell proliferation, and differentiation. By using XCT-790 to inhibit ERRα, researchers can better understand its functions and the consequences of its inhibition.
-==Potential Therapeutic Applications==
+XCT-790 functions by binding to the ligand-binding domain of ERR_, thereby inhibiting its activity. ERR_ is an orphan nuclear receptor, meaning it does not have a known endogenous ligand. XCT-790's ability to act as an inverse agonist makes it a valuable tool for investigating the physiological and pathological roles of ERR_ in various tissues.
-While XCT-790 is not currently used as a therapeutic drug in humans, its ability to inhibit ERRα suggests potential applications in the treatment of diseases where ERRα is overactive or dysregulated. These could include certain types of cancer, metabolic disorders, and cardiovascular diseases. However, more research is needed to fully understand the potential therapeutic applications of XCT-790.
-==Safety and Toxicity==
+== Biological Significance ==
-As a research compound, XCT-790 is not intended for human consumption. Its safety and toxicity in humans have not been fully studied. Therefore, it should be handled with care and used only by trained professionals in a laboratory setting.
+ERR_ is involved in the regulation of [[energy metabolism]], [[mitochondrial biogenesis]], and [[oxidative phosphorylation]]. It is highly expressed in tissues with high energy demands, such as the [[heart]], [[skeletal muscle]], and [[brown adipose tissue]]. By modulating ERR_ activity, XCT-790 can influence metabolic pathways and has been used to study conditions such as [[obesity]], [[diabetes]], and [[cancer]].
+== Research Applications ==
+XCT-790 is utilized in laboratory research to:
+* Investigate the role of ERR_ in [[metabolic disorders]].
+* Study the effects of ERR_ inhibition on [[cancer cell proliferation]] and survival.
+* Explore the potential therapeutic applications of ERR_ modulation in [[cardiovascular diseases]].
+== Safety and Handling ==
+As with many research chemicals, XCT-790 should be handled with care. Appropriate [[safety protocols]] should be followed, including the use of [[personal protective equipment]] (PPE) and working in a well-ventilated area or fume hood.
+== Related Pages ==
+* [[Estrogen-related receptor alpha]]
+* [[Nuclear receptor]]
+* [[Metabolic regulation]]
+* [[Inverse agonist]]
+[[Category:Chemical compounds]]
 [[Category:Pharmacology]]
-[[Category:Chemistry]]
+[[Category:Research tools]]
-[[Category:Biochemistry]]
-{{pharmacology-stub}}
-{{chemistry-stub}}
-{{biochemistry-stub}}