Calcium modulating ligand

Calcium Modulating Ligand or CAML is a protein that in humans is encoded by the CAMLG gene. It is a ubiquitous, highly conserved protein that plays a crucial role in cellular processes such as intracellular calcium homeostasis, protein trafficking, and cell survival.

Function

The CAML protein is involved in the regulation of intracellular calcium levels and it is necessary for the function of the calcium pump of the endoplasmic reticulum. It also plays a role in cellular survival and protein trafficking. It is a single-pass type III membrane protein that is located in the endoplasmic reticulum and it is involved in phospholipid metabolism in the Golgi apparatus.

Clinical Significance

Alterations in the function of the CAML protein have been associated with various diseases. For example, mutations in the CAMLG gene have been linked to congenital disorders of glycosylation. Moreover, the CAML protein has been implicated in the pathogenesis of cancer, as it is overexpressed in certain types of tumors.

See Also

• Calcium channel
• Calcium in biology
• Calcium pump
• Endoplasmic reticulum

References

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